Specially designed for nucleic acid extraction and purification, with surface modification of a large number of silanol groups (silanol groups), it can undergo specific binding with nucleic acids in solution under high salt and low pH conditions through hydrophobic, hydrogen bonding, and electrostatic interactions, without binding with other impurities (such as proteins), quickly separating nucleic acids from biological samples. The operation is safe and simple, which is very conducive to the automation and high-throughput extraction of nucleic acids. Used for bacterial genome DNA extraction, plant genome DNA extraction, peripheral blood genome DNA extraction, viral DNA&RNA extraction, HBV/HIV/HCV triple nucleic acid extraction, etc. The high magnetic content and moderate density ensure that the microspheres have good magnetic response speed and good resuspension under the action of a magnetic field, suitable for different types of automated instrument requirements.