Ammonia Methyl Resin CAS:89551-24-6 100-200mesh，1%DVB

Aminomethyl Polystyrene Resin for Linker Attachment

SHBC Aminomethyl Polystyrene Resin is an amino-functionalized, 1% DVB-crosslinked polystyrene support with a particle size of 100–200 mesh.

Its primary amine groups provide reactive sites for attaching carboxylic acid-containing linkers through stable amide bonds. It is widely used as a core resin for manufacturing Rink Amide, HMPA-AM and other customized solid-phase peptide synthesis supports.

Aminomethyl Resin is a base support rather than a ready-to-cleave peptide resin. The selected linker determines the final peptide C-terminus and cleavage conditions.

Product Specifications

Key Advantages of SHBC Aminomethyl Resin

Reactive Primary Amine Groups

The surface aminomethyl groups can be coupled with carboxylic acid-functionalized linkers using validated amide-bond formation chemistry.

Flexible Linker Selection

Different linkers can be installed to control peptide cleavage conditions, C-terminal functionality and downstream synthesis applications.

Stable Polystyrene Support

The 1% DVB-crosslinked polystyrene matrix provides mechanical structure while supporting swelling and reagent diffusion in compatible organic solvents.

Practical 100–200 Mesh Size

The 100–200 mesh particle size offers a useful balance between reagent accessibility, filtration, washing and batch handling.

Suitable for Custom Resin Manufacturing

Aminomethyl Resin can serve as a starting matrix for peptide synthesis resins, polymer-supported reagents, scavenger resins and other functionalized solid supports.

How Aminomethyl Resin Is Functionalized

A carboxylic acid-containing linker is attached to the primary amine group through a stable amide bond.

A general functionalization workflow includes:

1. Pre-swell the Aminomethyl Resin in a compatible solvent.

2. Activate the selected carboxylic acid-containing linker.

3. Couple the linker to the resin-bound primary amine.

4. Wash the resin and cap any remaining reactive sites.

5. Determine linker loading and free-amine conversion.

6. Load the first amino acid according to the selected linker.

7. Perform peptide synthesis and cleavage using a validated process.

The linker—not the base aminomethyl resin—determines whether the final product is a peptide acid, peptide amide or another functional derivative.

Applications

SHBC Aminomethyl Polystyrene Resin can be used for:

• Rink Amide AM Resin manufacturing

• HMPA-AM Resin preparation

• Custom peptide synthesis resin production

• Acid-labile or base-labile linker attachment

• Fmoc and Boc SPPS support development

• Solid-phase organic synthesis

• Polymer-supported reagent preparation

• Scavenger resin development

• Combinatorial chemistry

• Peptide and small-molecule library synthesis

• Immobilization of selected carboxyl-containing compounds

• Research-scale and batch resin manufacturing

Linker-modified AM Resin can support the synthesis of pharmaceutical peptides, antigenic peptides, epitope peptides and peptide reference materials.

Aminomethyl Resin in Peptide Synthesis

Aminomethyl Resin is commonly used as the polymer core for a cleavable linker. For example, attaching a Rink Amide linker produces a resin suitable for synthesizing C-terminal peptide amides by Fmoc chemistry.

Other linkers may be selected to produce peptide acids, protected peptide fragments or specialized peptide derivatives.

Direct attachment of a peptide to the base aminomethyl support is generally unsuitable when clean peptide cleavage is required.

Aminomethyl Resin vs Ready-to-Use SPPS Resins

Choose Aminomethyl Resin when custom linker selection and in-house resin functionalization are required.

Quality Control for Batch Production

For laboratory or batch resin manufacturing, evaluate:

• Primary amine loading

• Particle-size distribution

• DVB crosslinking percentage

• Moisture content

• Swelling performance

• Free-amine assay result

• Linker coupling efficiency

• Residual unreacted amine groups

• Filtration and washing behavior

• Lot-to-lot reproducibility

Pilot-scale linker coupling is recommended before transferring the process to larger batches.

Handling and Storage

Keep the resin tightly sealed in a cool, dry environment according to the product label and SDS.

Pre-swell the resin completely before linker coupling. Use compatible solvents and validated reaction conditions. Protect the resin from moisture, contamination and prolonged exposure to unsuitable conditions.

Frequently Asked Questions

What is Aminomethyl Polystyrene Resin?

It is a primary amine-functionalized polystyrene core resin used to attach linkers and prepare customized solid-phase synthesis supports.

Is Aminomethyl Resin ready for direct peptide synthesis?

It is normally functionalized with a cleavable linker before peptide synthesis. Direct peptide attachment may produce a bond that is difficult to cleave without damaging the product.

What peptide C-terminus does Aminomethyl Resin produce?

The C-terminus is determined by the attached linker. A Rink Amide linker produces a peptide amide, while other linkers can produce peptide acids or protected fragments.

What linkers can be attached?

Carboxylic acid-containing linkers, including Rink Amide and HMPA-type linkers, can be attached through stable amide bonds.

Can Aminomethyl Resin be used as a scavenger resin?

Yes. The primary amine groups can capture selected acids and electrophilic compounds in solution-phase synthesis.

Why is 1% DVB used?

DVB crosslinks the polystyrene matrix. A 1% crosslinking level supports resin structure while allowing useful swelling in compatible organic solvents.

What information is required for a bulk quotation?

Please provide the required quantity, target amine loading, intended linker, packaging requirement and required technical documents.

Request a Sample or Bulk Quote

SHBC supplies Aminomethyl Polystyrene Resin for linker attachment, custom SPPS resin development and batch functionalized resin manufacturing.

Contact Shanghai SanYu Biotechnology Co., Ltd. to discuss evaluation quantities, amine loading, bulk packaging, COA, SDS and quotation requirements.

For research and process-development use only.