Rink Amide AM Resin CAS183599-10-2 100-200mesh，1%DVB

Fmoc-Rink Amide AM Resin for Peptide Amide Synthesis

SHBC Rink Amide AM Resin is an acid-labile solid support designed for Fmoc solid-phase peptide synthesis (SPPS) of peptides with a C-terminal primary amide.

The resin consists of a modified Rink Amide linker attached to 1% DVB-crosslinked aminomethyl polystyrene. Its 100–200 mesh particle size supports practical swelling, reagent contact, filtration and washing.

It is suitable for research, process development and batch synthesis of amidated peptides.

Product Specifications

Key Advantages of SHBC Rink Amide AM Resin

Produces C-Terminal Peptide Amides

Cleavage from the Rink Amide linker releases a peptide with a C-terminal primary amide, avoiding an additional solution-phase amidation step.

Compatible with Fmoc SPPS

The resin supports standard Fmoc deprotection and amino acid coupling cycles used in manual and automated peptide synthesis.

Acid-Labile Peptide Release

The completed peptide can be released under validated acidic cleavage conditions, normally together with side-chain deprotection.

1% DVB Polystyrene Matrix

The crosslinked polystyrene matrix provides mechanical structure while supporting swelling and reagent diffusion in compatible SPPS solvents.

Practical 100–200 Mesh Size

The particle size provides a useful balance between coupling accessibility, filtration speed, washing and batch handling.

How Rink Amide AM Resin Works

The Rink Amide linker is attached to the aminomethyl polystyrene core through a stable bond. After removal of the Fmoc protecting group, the linker amine is available for coupling with the first protected amino acid.

A general synthesis workflow includes:

1. Pre-swell the resin in a compatible SPPS solvent.

2. Remove the Fmoc group from the Rink Amide linker.

3. Couple the protected C-terminal amino acid.

4. Perform repeated Fmoc deprotection and coupling cycles.

5. Wash the resin between reaction steps.

6. Cleave and deprotect the completed peptide under validated acidic conditions.

7. Purify and characterize the resulting peptide amide.

Cleavage and coupling conditions should be optimized for the peptide sequence, loading and synthesis scale.

Applications

SHBC Rink Amide AM Resin can be used for:

• C-terminal peptide amide synthesis

• Fmoc solid-phase peptide synthesis

• Therapeutic peptide research

• Peptide hormone and neuropeptide research

• Antigenic and epitope peptide production

• Immunoassay peptide standards

• Enzyme substrate peptides

• Peptide drug discovery

• Peptide library synthesis

• Modified and labeled peptide preparation

• Bioconjugation-ready peptide production

• Research-scale and batch peptide manufacturing

The resin is particularly useful when the target peptide requires a natural or designed C-terminal amide.

Rink Amide AM Resin vs Other SPPS Resins

Choose Rink Amide AM Resin when the required final product is a fully cleaved C-terminal peptide amide.

Loading Selection for Peptide Synthesis

Resin loading influences theoretical production capacity, reagent accessibility and aggregation risk.

Lower-loading resin may be preferred for long, hydrophobic or aggregation-prone peptides. Higher-loading resin may provide greater batch productivity for shorter and less demanding sequences.

When requesting a quotation, specify:

• Target loading range

• Peptide length

• Sequence characteristics

• Required batch size

• Manual or automated synthesis

• Packaging and documentation requirements

Quality Control and Handling

For resin qualification, evaluate:

• Linker loading or substitution

• Particle-size distribution

• DVB crosslinking percentage

• Fmoc content

• Moisture content

• Resin swelling performance

• First amino acid coupling efficiency

• Test cleavage performance

• Filtration behavior

• Lot-to-lot reproducibility

Keep the resin tightly sealed in a cool, dry environment according to the product label and SDS. Pre-swell the resin completely before use and validate all coupling and cleavage conditions.

Frequently Asked Questions

What is Rink Amide AM Resin used for?

It is used in Fmoc solid-phase peptide synthesis to produce peptides with a C-terminal primary amide.

What does AM mean in Rink Amide AM Resin?

AM refers to the aminomethyl polystyrene core on which the modified Rink Amide linker is installed.

What peptide C-terminus is obtained after cleavage?

Cleavage releases a peptide containing a C-terminal –CONH₂ group.

Is Rink Amide AM Resin compatible with Fmoc chemistry?

Yes. It is designed for Fmoc-based peptide-chain assembly.

What is the difference between Rink Amide AM Resin and Wang Resin?

Rink Amide AM Resin produces C-terminal peptide amides. Wang Resin produces peptides with a C-terminal carboxylic acid.

What is the difference between Rink Amide AM and Rink Amide MBHA Resin?

Both are used for peptide amide synthesis, but they use different polystyrene-based core supports. Loading, swelling and sequence performance should be evaluated for the intended process.

Is it suitable for long peptides?

It may be used for long peptides, but a lower loading level is often considered for aggregation-prone or sterically demanding sequences.

What information is required for a bulk quotation?

Please provide the required quantity, target loading, peptide length, synthesis scale, packaging and required quality documents.

Request a Sample or Bulk Quote

SHBC supplies Rink Amide AM Resin for Fmoc peptide amide synthesis, process development and batch production.

Contact Shanghai SanYu Biotechnology Co., Ltd. to discuss evaluation quantities, loading requirements, bulk packaging, COA, SDS and quotation details.

For research and process-development use only.