Wang Resin CAS:201058-08-4 100-200mesh,1% DVB

Wang Resin for Fmoc Solid-Phase Peptide Synthesis

SHBC Wang Resin is a 100–200 mesh, 1% DVB-crosslinked polystyrene support designed for Fmoc solid-phase peptide synthesis (SPPS).

The resin contains a p-alkoxybenzyl alcohol linker that forms an ester bond with the first Fmoc-protected amino acid. After peptide-chain assembly, acidic cleavage releases a peptide with a C-terminal carboxylic acid.

It is suitable for research, process development and batch synthesis of peptide acids.

Wang Resin Specifications

Key Advantages of SHBC Wang Resin

Designed for C-Terminal Peptide Acids

Wang Resin is a standard SPPS support for preparing peptides with a free C-terminal carboxylic acid after cleavage.

Stable Linkage During Fmoc Synthesis

The ester linkage provides suitable stability during repeated Fmoc deprotection, amino acid coupling and washing cycles. The completed peptide can then be released by acidic cleavage.

Good Swelling and Reagent Accessibility

The 1% DVB-crosslinked polystyrene matrix swells in common organic SPPS solvents, improving reagent diffusion into the resin beads.

Practical 100–200 Mesh Particle Size

The 100–200 mesh size provides a useful balance between reaction accessibility, mechanical handling, washing and filtration.

Suitable for Research and Batch Synthesis

The resin can be used in manual reactors, automated peptide synthesizers and validated batch production workflows.

How Wang Resin Works in Fmoc SPPS

The first Fmoc-protected amino acid is attached to the hydroxyl group of Wang Resin through an ester linkage. The peptide sequence is then assembled by repeated deprotection and coupling cycles.

A typical workflow includes:

1. Pre-swell the resin in a compatible SPPS solvent.

2. Attach the first Fmoc-protected amino acid.

3. Cap any remaining reactive sites.

4. Perform repeated Fmoc deprotection and amino acid coupling.

5. Wash the resin between reaction steps.

6. Cleave and deprotect the completed peptide.

7. Purify and characterize the resulting peptide acid.

Reaction conditions should be optimized according to the peptide sequence, resin loading and production scale.

Applications of Wang Resin

SHBC Wang Resin can be used for:

• Fmoc solid-phase peptide synthesis

• Linear peptide acid synthesis

• Antigenic peptide production

• Epitope peptide research

• Peptides for antibody development

• Immunoassay peptide development

• Peptide reference standards

• Enzyme substrate peptides

• Drug-discovery peptide libraries

• Linear precursors for selected cyclic peptide workflows

• Solid-phase immobilization of selected acids and phenols

For immunoassay applications, Wang Resin is used to manufacture antigenic, epitope or reference peptides. The resin itself is not added directly to the immunoassay.

Wang Resin vs 2-CTC Resin and Rink Amide Resin

Choose Wang Resin when the target product is a standard C-terminal peptide acid and mild cleavage of a protected fragment is not required.

Handling and Process Considerations

Pre-swell the resin completely before loading the first amino acid. Use compatible solvents and ensure sufficient mixing without damaging the resin beads.

For batch peptide synthesis, evaluate:

• Resin loading or substitution level

• Particle-size distribution

• Swelling performance

• Initial amino acid loading efficiency

• Coupling and cleavage efficiency

• Moisture content

• Filtration performance

• Lot-to-lot reproducibility

Store the resin tightly sealed in a cool, dry environment according to the product label and SDS.

Frequently Asked Questions

What is Wang Resin used for?

Wang Resin is primarily used as a solid support for Fmoc SPPS and the synthesis of peptides with a C-terminal carboxylic acid.

Is Wang Resin compatible with Fmoc chemistry?

Yes. Its linker is stable during standard Fmoc deprotection and amino acid coupling cycles.

What type of peptide does Wang Resin produce?

After cleavage, Wang Resin normally produces a peptide with a free C-terminal carboxylic acid.

When should I choose 2-CTC Resin instead?

Choose 2-CTC Resin when mild cleavage or recovery of a protected peptide fragment is required. Wang Resin is generally selected for conventional peptide acids cleaved under stronger acidic conditions.

Can Wang Resin produce C-terminal peptide amides?

No. Rink Amide Resin is normally recommended when the target peptide requires a C-terminal amide.

Is Wang Resin directly used in immunoassays?

No. It is an upstream synthesis carrier used to produce peptides that may later be applied as antigens, epitopes, controls or reference materials in immunoassay research.

What information is required for a bulk quotation?

Please provide the required quantity, target loading range, peptide synthesis scale, packaging requirement and required technical documents.

Request a Sample or Bulk Quote

SHBC supplies Wang Resin for peptide research, process development and batch peptide synthesis.

Contact Shanghai SanYu Biotechnology Co., Ltd. to discuss evaluation quantities, loading requirements, bulk packaging, COA, SDS and quotation details.

For research and process-development use only.