{"id":2346,"date":"2025-03-28T07:51:30","date_gmt":"2025-03-28T07:51:30","guid":{"rendered":"https:\/\/nanomicronspheres.com\/?p=2346"},"modified":"2025-03-28T08:12:40","modified_gmt":"2025-03-28T08:12:40","slug":"microspheres-drug-delivery-systems","status":"publish","type":"post","link":"https:\/\/nanomicronspheres.com\/zh\/microspheres-drug-delivery-systems\/","title":{"rendered":"\u5fae\u7403\u836f\u7269\u8f93\u9001\u7cfb\u7edf"},"content":{"rendered":"

\u7528\u4e8e\u836f\u7269\u8f93\u9001\u7684\u5fae\u7403<\/a> \u662f\u6307\u836f\u7269\u6eb6\u89e3\u6216\u5206\u6563\u4e8e\u9ad8\u5206\u5b50\u9aa8\u67b6\u6750\u6599\u4e2d\u5f62\u6210\u7684\u7403\u5f62\u9897\u7c92\uff0c\u7c92\u5f84\u4e00\u822c\u57281-250\u03bcm\u4e4b\u95f4\uff0c\u53ef\u7528\u4e8e\u9759\u8109\u6ce8\u5c04\u3001\u53e3\u670d\u3001\u8154\u5185\u5c40\u90e8\u7ed9\u836f\u6216\u76ae\u4e0b\u690d\u5165\u7b49\u4e0d\u540c\u7684\u7ed9\u836f\u9014\u5f84\u3002<\/p>\n

\"microspheres<\/p>\n

\u5fae\u7403\u5236\u5242\u53ef\u4ee5\u7f13\u6162\u91ca\u653e\u836f\u7269\uff0c\u4ece\u800c\u51cf\u5c11\u7ed9\u836f\u9891\u7387\uff0c\u964d\u4f4e\u8840\u836f\u6d53\u5ea6\u6ce2\u52a8\uff0c\u53d1\u6325\u957f\u671f\u6cbb\u7597\u4f5c\u7528\u3002\u5728\u5fae\u7403\u4e2d\u5f15\u5165\u78c1\u6027\u7269\u8d28\u6216\u4fee\u9970\u8f7d\u4f53\u6750\u6599\uff0c\u53ef\u4f7f\u5fae\u7403\u78c1\u6027\u6216\u4e3b\u52a8\u9776\u5411\u75c5\u7076\uff0c\u63d0\u9ad8\u9776\u90e8\u4f4d\u6709\u6548\u8840\u836f\u6d53\u5ea6\uff0c\u964d\u4f4e\u836f\u7269\u7684\u5168\u8eab\u6bd2\u526f\u4f5c\u7528\u3002\u5c06\u5fae\u7403\u5f15\u5165\u80bf\u7624\u52a8\u8109\uff0c\u53ef\u901a\u8fc7\u6813\u585e\u6cbb\u7597\u6740\u4f24\u80bf\u7624\u7ec6\u80de\uff0c\u5728\u91ca\u653e\u836f\u7269\u7684\u540c\u65f6\u963b\u65ad\u80bf\u7624\u7684\u8425\u517b\u548c\u8840\u6db2\u4f9b\u5e94\uff0c\u8fdb\u4e00\u6b65\u589e\u52a0\u6cbb\u7597\u6548\u679c\u3002\u6b64\u5916\uff0c\u5fae\u7403\u5236\u5242\u8fd8\u53ef\u4ee5\u63a9\u76d6\u836f\u7269\u7684\u96be\u95fb\u6c14\u5473\uff0c\u51cf\u5c11\u523a\u6fc0\u6027\uff0c\u63d0\u9ad8\u836f\u7269\u7a33\u5b9a\u6027\u3002<\/p>\n

\u7279\u522b\u662f\u5fae\u7403\u836f\u7269\u9012\u9001\u7cfb\u7edf\u53ef\u4ee5\u5229\u7528\u81ea\u8eab\u7684\u4f18\u52bf\u5b9e\u73b0\u5c0f\u5206\u5b50\u836f\u7269\u3001\u591a\u80bd\u3001\u86cb\u767d\u8d28\u7b49\u5927\u5206\u5b50\u836f\u7269\u4ee5\u53ca\u5de5\u7a0b\u7ec6\u80de\u7684\u5c40\u90e8\u9012\u9001\u3002<\/p>\n

\"Drug
\u836f\u7269\u9012\u9001\u5fae\u7403\u91ca\u653e\u5316\u7597\u836f\u7269<\/figcaption><\/figure>\n

\u4f8b\u5982\uff0c\u5fae\u7403\u53ef\u4ee5\u4fc3\u8fdb\u9aa8\u9ad3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de(BMSCs)\u7684\u9ecf\u9644\u548c\u589e\u6b96\uff0c\u5c06\u5fae\u7403\u690d\u5165\u9aa8\u7f3a\u635f\u5185\u53ef\u4fc3\u8fdb\u9aa8\u5f62\u6210\uff1b\u7528\u4e8e\u7ecf\u52a8\u8109\u5316\u7597\u6813\u585e\u672f(TACE)\u65f6\uff0c\u53ef\u6839\u636e\u8840\u7ba1\u7ba1\u5f84\u548c\u6cbb\u7597\u8981\u6c42\u6309\u9700\u5236\u5907\u5fae\u7403\uff0c\u4ee5\u8fbe\u5230\u66f4\u7cbe\u51c6\u7684\u6813\u585e\u6548\u679c\uff1b\u5c06\u5fae\u7403\u5236\u5907\u6210\u591a\u5b54\u3001\u591a\u5c42\u7ed3\u6784\uff0c\u8d1f\u8f7d\u4e0d\u540c\u7684\u5185\u5bb9\u7269\uff0c\u540c\u65f6\u5728\u4f53\u5185\u5f62\u6210\u957f\u6548\u7684\u836f\u7269\u50a8\u5e93\uff1b\u5229\u7528\u4e0d\u540c\u6750\u6599\u964d\u89e3\u901f\u5ea6\u7684\u5dee\u5f02\uff0c\u5b9e\u73b0\u836f\u7269\u7684\u5e8f\u8d2f\u6216\u68af\u5ea6\u91ca\u653e\u3002<\/p>\n

\u5fae\u7403\u5236\u5242\u5728\u533b\u7597\u9886\u57df\u7684\u5e94\u7528\u53d6\u5f97\u91cd\u5927\u8fdb\u5c55\uff0c\u591a\u4e2a\u4ea7\u54c1\u6210\u529f\u4e0a\u5e02\uff0c\u4e3a\u591a\u79cd\u75be\u75c5\u63d0\u4f9b\u4e86\u521b\u65b0\u7684\u6cbb\u7597\u7b56\u7565\u3002<\/p>\n

1. \u836f\u7269\u9012\u9001\u5fae\u7403\u7684\u5236\u5907\u65b9\u6cd5<\/strong><\/h2>\n

\u836f\u7269\u7f13\u91ca\u5fae\u7403\u7684\u5236\u5907\u8fc7\u7a0b\u901a\u5e38\u5305\u62ec\u5206\u6563\u3001\u56fa\u5316\u3001\u6d17\u6da4\u548c\u5e72\u71e5\u56db\u4e2a\u6b65\u9aa4\u3002\u5206\u6563\u662f\u6307\u901a\u8fc7\u4e73\u5316\u3001\u63a7\u5236\u6eb6\u8d28\u6eb6\u89e3\u5ea6\u7b49\u65b9\u6cd5\u5c06\u836f\u7269\u5747\u5300\u5206\u5e03\u5230\u805a\u5408\u7269\u57fa\u8d28\u4e2d\uff0c\u5f62\u6210\u5fae\u7403\u7ed3\u6784\u3002\u56fa\u5316\u662f\u901a\u8fc7\u7269\u7406\u65b9\u6cd5\uff08\u5982\u6eb6\u5242\u84b8\u53d1\u3001\u6e29\u5ea6\u53d8\u5316\uff09\u6216\u5316\u5b66\u65b9\u6cd5\uff08\u5982\u4ea4\u8054\u53cd\u5e94\uff09\u56fa\u5b9a\u5fae\u7403\u7684\u5f62\u8c8c\u548c\u7ed3\u6784\uff0c\u518d\u7ecf\u8fc7\u6d17\u6da4\u3001\u5e72\u71e5\u53bb\u9664\u6742\u8d28\uff0c\u5f97\u5230\u53ef\u4ee5\u50a8\u5b58\u7684\u5fae\u7403\u9897\u7c92\u3002\u672c\u6587\u6839\u636e\u4e0d\u540c\u7684\u5236\u5907\u65b9\u6cd5\u5bf9\u8f7d\u836f\u5fae\u7403\u8fdb\u884c\u5206\u7c7b\uff0c\u5e76\u5206\u6790\u6bcf\u79cd\u65b9\u6cd5\u7684\u6838\u5fc3\u5de5\u5e8f\u3002<\/p>\n

\"microspheres<\/p>\n

2.\u4e34\u5e8a\u5e94\u7528\u00a0 <\/strong>\u5fae\u7403<\/strong>s <\/strong>\u836f\u7269\u8f93\u9001<\/strong> \u7cfb\u7edf<\/strong><\/h2>\n

2.1 \u6076\u6027\u80bf\u7624\u7684\u5c40\u90e8\u6cbb\u7597<\/strong><\/h3>\n

\u6076\u6027\u80bf\u7624\uff08\u764c\u75c7\uff09\u662f\u5a01\u80c1\u6211\u56fd\u793e\u4f1a\u7a33\u5b9a\u548c\u7ecf\u6d4e\u53d1\u5c55\u7684\u91cd\u5927\u75be\u75c5\uff0c2022\u5e74\u6211\u56fd\u5c06\u6709\u7ea6480\u4e07\u764c\u75c7\u65b0\u53d1\u75c5\u4f8b\u548c250\u4e07\u764c\u75c7\u6b7b\u4ea1\u75c5\u4f8b\u3002\u76ee\u524d\u4e34\u5e8a\u4e0a\u4f7f\u7528\u7684\u6297\u80bf\u7624\u836f\u7269\u4e3b\u8981\u6709\u5206\u5b50\u9776\u5411\u836f\u7269\u3001\u5316\u7597\u836f\u7269\u3001\u514d\u75ab\u6cbb\u7597\u836f\u7269\u3001\u7ec6\u80de\u6cbb\u7597\u7b49\u3002\u5c06\u6297\u80bf\u7624\u836f\u7269\u5c01\u88c5\u5728\u5fae\u7403\u4e2d\uff0c\u4e0d\u4ec5\u80fd\u5ef6\u7f13\u91ca\u653e\u901f\u5ea6\u3001\u6301\u7eed\u6740\u4f24\u80bf\u7624\u7ec6\u80de\u3001\u514b\u670d\u8010\u836f\u6027\u7684\u53d1\u751f\u548c\u7ed9\u836f\u9891\u7387\uff0c\u8fd8\u80fd\u901a\u8fc7\u5c40\u90e8\u6216\u539f\u4f4d\u7ed9\u836f\u7b56\u7565\u51cf\u5c11\u4e0d\u826f\u53cd\u5e94\u3002<\/p>\n

\u5e2d\u7b49\u91c7\u7528\u53cc\u6d17\u5242\u6cd5\u548c\u6eb6\u5242\u8403\u53d6\u6cd5\u5236\u5907\u4e86\u591a\u5b54\u805a\u4e73\u9178\uff08PLA\uff09\u5fae\u7403\uff0c\u5229\u7528PLA\u7684\u81ea\u4fee\u590d\u7279\u6027\uff0c\u6e29\u548c\u7684\u7ea2\u5916\u5149\u7167\u5c04\u5f15\u8d77\u6e29\u5ea6\u5347\u9ad8\uff0c\u4f7fPLA\u7531\u73bb\u7483\u6001\u8f6c\u53d8\u4e3a\u6a61\u80f6\u6001\uff0c\u5f15\u53d1\u805a\u5408\u7269\u94fe\u7684\u81ea\u53d1\u91cd\u6392\uff0c\u8fd9\u79cd\u591a\u5b54\u5fae\u7403\u5c06\u53d1\u751f\u4fee\u590d\uff0c\u5c06\u6297\u539f\u5206\u5b50\u8d1f\u8f7d\u5230\u5fae\u7403\u4e2d\uff0c\u8fbe\u5230\u7f13\u91ca\u6548\u679c\u3002<\/p>\n

\u5fae\u7403\u8fd8\u53ef\u5305\u8986\u5404\u79cd\u9020\u5f71\u5242\u7528\u4e8e\u4f53\u5185\u6210\u50cf\uff0c\u5f20\u7b49\u7ed3\u5408\u9759\u7535\u7eba\u4e1d\u3001\u5747\u8d28\u548c\u7535\u55b7\u96fe\u6280\u672f\uff0c\u5236\u5907\u51fa\u900f\u660e\u8d28\u9178\u529f\u80fd\u5316\u7684\u8f7d\u836f\u7ea4\u7ef4\u5fae\u7403\uff0c\u5fae\u7403\u4e0a\u87af\u5408\u7684Gd3+\u53ef\u5b9e\u73b0\u80bf\u7624\u81f3\u5c115\u5929\u7684\u78c1\u5171\u632f\u6210\u50cf\u3002<\/p>\n

\u4e3a\u9632\u6b62\u5b9e\u4f53\u80bf\u7624\u5207\u9664\u540e\u8f6c\u79fb\u590d\u53d1\uff0c\u672f\u540e\u5e38\u91c7\u7528\u5316\u7597\u6216\u653e\u7597\u7b49\u8f85\u52a9\u6cbb\u7597\u3002\u4f46\u5316\u7597\u836f\u7269\u5168\u8eab\u7ed9\u836f\u540e\u5230\u8fbe\u9776\u5668\u5b98\u7684\u6d53\u5ea6\u6709\u9650\uff0c\u4e14\u8fbe\u5230\u4e00\u5b9a\u7684\u836f\u7269\u6d53\u5ea6\u9700\u8981\u8f83\u5927\u7684\u5242\u91cf\uff0c\u5bb9\u6613\u5bfc\u81f4\u5168\u8eab\u6bd2\u526f\u4f5c\u7528\u3002\u949f\u7b49\u91c7\u7528\u5fae\u6d41\u63a7\u6cd5\u548c\u7535\u55b7\u96fe\u6cd5\u5236\u5907\u4e86\u542b\u6709\u591a\u4e2a\u7532\u57fa\u4e19\u70ef\u9170\u660e\u80f6\uff08GelMA\uff09\u5fae\u7403\u7684\u6d77\u85fb\u9178\u9499\u5fae\u7403\u3002<\/p>\n

\"microsphere<\/p>\n

\u6d77\u85fb\u9178\u9499\u5fae\u7403\u5728\u80bf\u7624\u5207\u9664\u90e8\u4f4d\u539f\u4f4d\u586b\u5145\uff0c\u6d77\u85fb\u9178\u9499\u5fae\u7403\u5feb\u901f\u964d\u89e3\uff0c\u5feb\u901f\u91ca\u653e\u963f\u9709\u7d20\uff0c\u6740\u6b7b\u6b8b\u7559\u80bf\u7624\u7ec6\u80de\uff1bGelMA\u5fae\u7403\u964d\u89e3\u7f13\u6162\uff0c\u6301\u7eed\u91ca\u653e\u5305\u88f9\u7684\u809d\u518d\u751f\u4fc3\u8fdb\u5242\uff0cGelMA\u5fae\u7403\u8fd8\u53ef\u4f5c\u4e3a\u809d\u7ec6\u80de\u518d\u751f\u652f\u67b6\uff0c\u4fc3\u8fdb\u809d\u810f\u518d\u751f\u3002<\/p>\n

\u8fd1\u5e74\u6765\uff0c\u5d4c\u5408\u6297\u539f\u53d7\u4f53T\u7ec6\u80de\uff08CAR-T\uff09\u7597\u6cd5\u5728\u8840\u6db2\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u6cbb\u7597\u4e2d\u53d6\u5f97\u4e86\u6709\u6548\u4e14\u6301\u4e45\u7684\u4e34\u5e8a\u53cd\u5e94\uff0c\u6709\u671b\u6539\u53d8\u8840\u6db2\u7cfb\u7edf\u80bf\u7624\u6cbb\u7597\u7684\u73b0\u72b6\u3002\u4f46\u76ee\u524dCAR-T\u7597\u6cd5\u5728\u5b9e\u4f53\u7624\u4e2d\u7684\u7597\u6548\u6709\u9650\uff0c\u4e3b\u8981\u539f\u56e0\u662f\u5b9e\u4f53\u7624\u81f4\u5bc6\u7684\u7ec6\u80de\u5916\u57fa\u8d28\u548c\u5f02\u5e38\u7684\u8840\u7ba1\u7cfb\u7edf\u9650\u5236\u4e86CAR-T\u7ec6\u80de\u7684\u80bf\u7624\u6d78\u6da6\u3002<\/p>\n

Liao\u7b49\u53d7\u5230T\u7ec6\u80de\u5728\u6dcb\u5df4\u7ed3\u4e2d\u589e\u6b96\u7684\u751f\u7406\u8fc7\u7a0b\u7684\u542f\u53d1\uff0c\u91c7\u7528\u5fae\u6d41\u63a7\u6cd5\u5236\u5907\u4e86PLGA\u5fae\u7403\u4eba\u5de5\u6dcb\u5df4\u7ed3\u652f\u67b6\uff0c\u7528\u4e8e\u8d1f\u8f7dCAR-T\u7ec6\u80de\u5e76\u5305\u8986\u591a\u79cd\u7ec6\u80de\u56e0\u5b50\uff0c\u6a21\u62df\u6297\u539f\u5448\u9012\u7ec6\u80de\uff08APC\uff09\u63d0\u4f9b\u7684\u5173\u952e\u4fe1\u53f7\u5206\u5b50\u6765\u6fc0\u6d3bT\u7ec6\u80de\u3002<\/p>\n

2.2\u7528\u4e8e\u9aa8\u7f3a\u635f\u4fee\u590d\u7b49\u9aa8\u79d1\u75be\u75c5\u6cbb\u7597<\/strong><\/h3>\n

\u9aa8\u635f\u4f24\u5fae\u73af\u5883\u5177\u6709\u708e\u75c7\u3001\u9178\u6027\u3001\u6d3b\u6027\u6c27\uff08ROS\uff09\u9ad8\u8868\u8fbe\u7b49\u7279\u70b9\uff0c\u7ec6\u80de\u56e0\u5b50\u7b49\u836f\u7269\u5728\u9aa8\u7f3a\u635f\u4fee\u590d\u4e2d\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u4f46\u7531\u4e8e\u7ec6\u80de\u56e0\u5b50\u65e0\u6cd5\u5728\u590d\u6742\u7684\u673a\u4f53\u73af\u5883\u4e2d\u7ef4\u6301\u957f\u671f\u6d3b\u6027\uff0c\u9650\u5236\u4e86\u5176\u5e94\u7528\u3002\u5fae\u7403\u53ef\u4ee5\u4e3a\u5176\u63d0\u4f9b\u7a33\u5b9a\u7684\u5fae\u73af\u5883\uff0c\u4f7f\u5176\u80fd\u957f\u65f6\u95f4\u4fdd\u7559\u6d3b\u6027\uff0c\u8fbe\u5230\u7f13\u91ca\u6548\u679c\uff0c\u800c\u4e14\u5fae\u7403\u7684\u53ef\u6ce8\u5c04\u6027\u4f7f\u5176\u80fd\u591f\u690d\u5165\u60a3\u8005\u4f53\u5185\uff0c\u586b\u5145\u4e0d\u89c4\u5219\u7684\u9aa8\u7f3a\u635f\u533a\u57df\u3002Song\u7b49\u5c06\u4e8c\u6c27\u5316\u9530\uff08MnO2\uff09\u7eb3\u7c73\u7c92\u5b50\u548c\u9aa8\u5f62\u6001\u53d1\u751f\u86cb\u767d-2\uff08BMP-2\uff09\u8d1f\u8f7d\u5230PLGA\u5fae\u7403\u4e0a\uff0c\u5229\u7528\u4f4e\u9891\u8d85\u58f0\u6280\u672f\u5b9e\u73b0\u4e86\u836f\u7269\u7684\u54cd\u5e94\u6027\u6309\u9700\u91ca\u653e\u3002<\/p>\n

\"Streptavidin
SHBC \u94fe\u9709\u4eb2\u548c\u7d20\u5fae\u7403<\/a><\/figcaption><\/figure>\n

\u867d\u7136\u9aa8\u7ec4\u7ec7\u5177\u6709\u4e00\u5b9a\u7684\u518d\u751f\u80fd\u529b\uff0c\u4f46\u662f\u5bf9\u4e8e\u9762\u79ef\u8f83\u5927\u3001\u8d85\u51fa\u9aa8\u7ec4\u7ec7\u81ea\u6108\u80fd\u529b\u7684\u9aa8\u7f3a\u635f\uff0c\u901a\u5e38\u9700\u8981\u9aa8\u79fb\u690d\u690d\u5165\u624d\u80fd\u8fbe\u5230\u6709\u6548\u7684\u6cbb\u7597\u6548\u679c\u3002\u90dd\u7b49\u91c7\u7528\u5fae\u6d41\u63a7\u6cd5\u5236\u5907\u4e86\u5305\u8986\u8131\u9499\u9aa8\u57fa\u8d28\uff08DBM\uff09\u7c89\u672b\u548c\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u7684GelMA\/\u7532\u57fa\u4e19\u70ef\u9170\u900f\u660e\u8d28\u9178\uff08HAMA\uff09\u5fae\u7403\uff0c\u5e76\u5c06\u5fae\u7403\u88c5\u8f7d\u5230DBM\u652f\u67b6\u4e2d\u690d\u5165\u9aa8\u7f3a\u635f\u5185\u3002<\/p>\n

\u4e0e\u5757\u72b6\u6c34\u51dd\u80f6\u76f8\u6bd4\uff0c\u5fae\u7403\u8868\u9762\u8d1f\u8f7d\u7684\u7ec6\u80de\u80fd\u591f\u4e0e\u7ec6\u80de\u5916\u57fa\u8d28\u5145\u5206\u63a5\u89e6\uff0c\u5fae\u7403\u7684\u5b54\u9699\u4e5f\u4fdd\u8bc1\u4e86\u8425\u517b\u7269\u8d28\u7684\u6e17\u900f\u548c\u8fd0\u8f93\uff0c\u540c\u65f6\u5fae\u7403\u95f4\u7684\u5b54\u9699\u6709\u5229\u4e8e\u8840\u7ba1\u7684\u5f62\u6210\uff0c\u53ef\u4ee5\u6709\u6548\u4fc3\u8fdbBMSCs\u7684\u9ecf\u9644\u3001\u589e\u6b96\u548c\u6210\u9aa8\u5206\u5316\u3002<\/p>\n

2.3\u7528\u4e8e\u6cbb\u7597\u810a\u9ad3\u635f\u4f24\u7b49\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5<\/strong><\/h3>\n

\u795e\u7ecf\u635f\u4f24\u5305\u62ec\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u635f\u4f24\u548c\u5468\u56f4\u795e\u7ecf\u7cfb\u7edf\u635f\u4f24\uff0c\u4e8c\u8005\u5747\u7ed9\u4e34\u5e8a\u6cbb\u7597\u548c\u529f\u80fd\u5eb7\u590d\u5e26\u6765\u6311\u6218\uff0c\u5c24\u5176\u662f\u810a\u9ad3\u635f\u4f24\u3002\u5168\u7403\u6bcf\u767e\u4e07\u4eba\u4e2d\u7ea6\u670940\u4f8b\u810a\u9ad3\u635f\u4f24\uff0c\u82e5\u5f97\u4e0d\u5230\u6709\u6548\u6cbb\u7597\uff0c\u810a\u9ad3\u635f\u4f24\u5f80\u5f80\u5bfc\u81f4\u7ec8\u8eab\u6b8b\u75be\u3002\u76ee\u524d\uff0c\u5c06\u795e\u7ecf\u5e72\u7ec6\u80de\u79fb\u690d\u5230\u810a\u9ad3\u635f\u4f24\u90e8\u4f4d\u88ab\u8ba4\u4e3a\u662f\u4e00\u79cd\u5f88\u6709\u524d\u666f\u7684\u6cbb\u7597\u7b56\u7565\u3002\u7136\u800c\uff0c\u7531\u4e8e\u75c5\u7406\u5fae\u73af\u5883\u7684\u5f71\u54cd\uff0c\u79fb\u690d\u7ec6\u80de\u7684\u5b58\u6d3b\u7387\u548c\u5206\u5316\u6548\u7387\u76f8\u5bf9\u8f83\u4f4e\u3002<\/p>\n

\u5434\u7b49\u5236\u5907\u4e86\u8840\u5c0f\u677f\u884d\u751f\u751f\u957f\u56e0\u5b50\uff08PDGF\uff09\u6a21\u62df\u80bd\u5fae\u7403\uff0c\u8be5\u5fae\u7403\u7531\u4e94\u80bdVRKKP\u5728PDGF\u5e8f\u5217\u6b8b\u57fa159~163\u4e4b\u95f4\u4e0e\u8418\u4e59\u9178-\u82ef\u4e19\u6c28\u9178-\u82ef\u4e19\u6c28\u9178-\u7518\u6c28\u9178\u8fde\u63a5\u751f\u6210\u81ea\u7ec4\u88c5\u6c34\u51dd\u80f6\u5fae\u7403\u3002\u5176\u4e2d\u4e94\u80bdVRKKP\u53ef\u4ee5\u6a21\u62dfPDGF\u7684\u529f\u80fd\uff0c\u5305\u62ec\u9632\u6b62\u795e\u7ecf\u5143\u6b7b\u4ea1\u3001\u63d0\u9ad8NSC\u5206\u5316\u6548\u7387\u7b49\uff0c\u4ece\u800c\u63d0\u9ad8NSC\u79fb\u690d\u5b58\u6d3b\u7387\uff0c\u53d1\u6325\u534f\u540c\u6548\u5e94\u3002<\/p>\n

2.4\u7528\u4e8e\u6cbb\u7597\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u611f\u67d3\u7b49\u547c\u5438\u7cfb\u7edf\u75be\u75c5<\/strong><\/h3>\n

\u4e25\u91cd\u6025\u6027\u547c\u5438\u7efc\u5408\u5f81\u51a0\u72b6\u75c5\u6bd22\uff08SARS-CoV-2\uff09\u662f\u4e00\u79cd\u4f20\u67d3\u6027\u5f3a\u3001\u81f4\u75c5\u6027\u5f3a\u7684\u75c5\u6bd2\uff0c\u4f1a\u5f15\u8d77\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u611f\u67d3\uff08coronavirus disease2019\uff0cCOVID-19\uff09\uff0c\u5f15\u8d77\u6025\u6027\u547c\u5438\u9053\u611f\u67d3\u3002\u76ee\u524d\u75ab\u82d7\u5f80\u5f80\u9700\u8981\u591a\u6b21\u6ce8\u5c04\u624d\u80fd\u5b8c\u5168\u6fc0\u6d3b\u514d\u75ab\u7cfb\u7edf\u3002\u5fae\u7403\u7ed9\u836f\u7cfb\u7edf\u5177\u6709\u63d0\u9ad8\u836f\u7269\u7a33\u5b9a\u6027\u548c\u836f\u7269\u957f\u671f\u7f13\u91ca\u7684\u6548\u679c\uff0c\u53ef\u4ee5\u5305\u8986\u4e00\u4e9b\u54cd\u5e94\u6027\u6750\u6599\u5982\u6c27\u5316\u94c1\u7eb3\u7c73\u9897\u7c92\u800c\u5177\u6709\u9776\u5411\u6027\uff0c\u53ef\u4ee5\u5c06\u75ab\u82d7\u7cbe\u51c6\u5730\u9012\u9001\u5230APC\uff0c\u8fbe\u5230\u66f4\u597d\u7684\u514d\u75ab\u6548\u679c\u3002<\/p>\n

Chen \u7b49\u5229\u7528\u53cc\u5149\u5b50\u805a\u54083D\u6fc0\u5149\u5149\u523b\u6280\u672f\u5236\u5907\u4e86GelMA\u5fae\u7403\u7528\u4e8eDNA\u75ab\u82d7\u9012\u9001\uff08\u56fe3A\uff09\uff0c\u901a\u8fc7\u6539\u53d8\u6fc0\u5149\u529f\u7387\u53ef\u4ee5\u8c03\u8282\u5fae\u7403\u7684\u4ea4\u8054\u7a0b\u5ea6\uff0c\u4ece\u800c\u63a7\u5236\u836f\u7269\u7684\u91ca\u653e\u3002\u901a\u8fc7\u5728\u78c1\u6027\u652f\u67b6\u4e0a\u5236\u5907GelMA\u5fae\u7403\uff0c\u53ef\u4ee5\u5b9e\u73b0\u53ef\u64cd\u4f5c\u6027\u548c\u9776\u5411\u6027\uff0c\u5c06DNA\u75ab\u82d7\u9012\u9001\u81f3\u6811\u7a81\u72b6\u7ec6\u80de\u548c\u539f\u4ee3\u7ec6\u80de\uff0c\u51cf\u5c11\u8131\u9776\u6548\u5e94\uff0c\u5b9e\u73b0\u75ab\u82d7\u7684\u9776\u5411\u9012\u9001\u3002<\/p>\n

2.5 \u7528\u4e8e\u8c03\u8282\u80a0\u9053\u83cc\u7fa4<\/strong><\/h3>\n

\u7814\u7a76\u663e\u793a\u80a0\u9053\u83cc\u7fa4\u5728\u708e\u75c7\u6027\u80a0\u75c5\u4e43\u81f3\u6574\u4e2a\u514d\u75ab\u7cfb\u7edf\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\uff0c\u53e3\u670d\u76ca\u751f\u83cc\u53ef\u901a\u8fc7\u8c03\u8282\u80a0\u9053\u83cc\u7fa4\u6765\u6cbb\u7597\u80c3\u80a0\u9053\u75be\u75c5\uff0c\u4f46\u80c3\u80a0\u9053\u73af\u5883\u6761\u4ef6\uff08\u5982\u80c3\u9178\u548c\u5404\u79cd\u6d88\u5316\u9176\u7684\u5b58\u5728\uff09\u5bfc\u81f4\u53e3\u670d\u76ca\u751f\u83cc\u5b58\u6d3b\u7387\u4f4e\u3001\u5b9a\u690d\u4e0d\u5145\u5206\uff0c\u5927\u5927\u9650\u5236\u4e86\u5176\u5e94\u7528\u3002\u6768\u7b49\u5c06\u7532\u57fa\u4e19\u70ef\u9178\u916f\u5f15\u5165\u8461\u805a\u7cd6\u548c\u5355\u5b81\u9178\uff08TA\uff09\uff0c\u5c06\u4e24\u79cd\u6eb6\u6db2\u6df7\u5408\uff0c\u5728\u53ef\u89c1\u5149\uff08405nm\uff09\u4e0b\u56fa\u5316\u3002<\/p>\n

\u5236\u5907\u7684\u6c34\u51dd\u80f6\u5fae\u7403\u7528\u4e8e\u5305\u8986\u5927\u80a0\u6746\u83ccNissle1917\u548c\u5432\u54da-3-\u4e19\u9178\uff08\u56fe4\uff09\uff0c\u8be5\u5fae\u7403\u517c\u5177\u679c\u80f6\u5728\u80c3\u548c\u5c0f\u80a0\u7684\u7a33\u5b9a\u6027\u548c\u5bcc\u542b\u513f\u8336\u915a\u57fa\u56e2\u7684TA\u5728\u80a0\u9053\u7684\u9ecf\u9644\u6027\uff0c\u5728\u5c0f\u9f20\u7ed3\u80a0\u708e\u6a21\u578b\u4e2d\u4f7f\u7528\u8be5\u5fae\u7403\u53ef\u51cf\u8f7b\u80a0\u9053\u708e\u75c7\uff0c\u6062\u590d\u80a0\u9053\u5c4f\u969c\u529f\u80fd\u3002<\/p>\n

\u7ed3\u8bba\u4e0e\u5c55\u671b<\/strong><\/h2>\n

\u672c\u6587\u7cfb\u7edf\u603b\u7ed3\u4e86\u5fae\u7403\u7ed9\u836f\u7cfb\u7edf\u7684\u5236\u5907\u65b9\u6cd5\u548c\u4e34\u5e8a\u5e94\u7528\uff0c\u5e76\u8ba8\u8bba\u4e86\u65b0\u578b\u5fae\u7403\u7ed9\u836f\u7cfb\u7edf\u5728\u4e34\u5e8a\u8f6c\u5316\u4e2d\u9762\u4e34\u7684\u6311\u6218\u3002\u73b0\u6709\u7684\u5236\u5907\u8f7d\u836f\u5fae\u7403\u7684\u65b9\u6cd5\uff0c\u5982\u4e73\u5316\u6eb6\u5242\u84b8\u53d1\u6cd5\u548c\u76f8\u5206\u79bb\u6cd5\uff0c\u867d\u7136\u5b58\u5728\u7c92\u5f84\u5206\u5e03\u4e0d\u5747\u5300\u3001\u4f7f\u7528\u5927\u91cf\u6709\u673a\u6eb6\u5242\u7b49\u7f3a\u70b9\uff0c\u4f46\u5177\u6709\u6210\u672c\u4f18\u52bf\uff0c\u66f4\u9002\u5408\u5927\u89c4\u6a21\u751f\u4ea7\u3002<\/p>\n

\u819c\u4e73\u5316\u6cd5\u3001\u5fae\u6d41\u63a7\u6cd5\u3001\u8d85\u4e34\u754c\u6d41\u4f53\u6cd5\u7b49\u56e0\u5176\u7c92\u5f84\u5747\u5300\u3001\u5206\u5e03\u53ef\u63a7\u3001\u73af\u5883\u53cb\u597d\u7b49\u4f18\u52bf\u9010\u6e10\u6210\u4e3a\u7814\u7a76\u70ed\u70b9\u3002\u5c06\u4e0d\u540c\u7684\u5fae\u7403\u5236\u5907\u6280\u672f\u7ec4\u5408\u8d77\u6765\uff0c\u53ef\u4ee5\u5f97\u5230\u6027\u80fd\u66f4\u4f18\u5f02\u7684\u8f7d\u836f\u5fae\u7403\u6216\u6ee1\u8db3\u7279\u5b9a\u7684\u5e94\u7528\u9700\u6c42\u3002<\/p>\n

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\"NHS
SHBC\u78c1\u73e0<\/a><\/figcaption><\/figure>\n

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\u968f\u7740\u7814\u7a76\u7684\u6df1\u5165\u548c\u6280\u672f\u7684\u8fdb\u6b65\uff0c\u836f\u7269\u5f00\u53d1\u5546\u6709\u671b\u8bbe\u8ba1\u548c\u5f00\u53d1\u51fa\u7f13\/\u63a7\u91ca\u6548\u679c\u66f4\u4f73\u3001\u751f\u4ea7\u5de5\u827a\u66f4\u4e3a\u5b8c\u5584\u7684\u836f\u7269\u9012\u9001\u5fae\u7403\u4ea7\u54c1\u3002<\/p>","protected":false},"excerpt":{"rendered":"

Microspheres for drug delivery refer to spherical particles formed by the dissolution or dispersion of drugs in polymer matrix materials, with a particle size generally between 1-250 \u03bcm. They can be used for different administration routes such as intravenous injection, oral administration, local administration through the cavity, or subcutaneous implantation. Microsphere formulations can slowly release […]<\/p>\n","protected":false},"author":1,"featured_media":2350,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2346","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/nanomicronspheres.com\/zh\/wp-json\/wp\/v2\/posts\/2346","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanomicronspheres.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nanomicronspheres.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nanomicronspheres.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nanomicronspheres.com\/zh\/wp-json\/wp\/v2\/comments?post=2346"}],"version-history":[{"count":2,"href":"https:\/\/nanomicronspheres.com\/zh\/wp-json\/wp\/v2\/posts\/2346\/revisions"}],"predecessor-version":[{"id":2355,"href":"https:\/\/nanomicronspheres.com\/zh\/wp-json\/wp\/v2\/posts\/2346\/revisions\/2355"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nanomicronspheres.com\/zh\/wp-json\/wp\/v2\/media\/2350"}],"wp:attachment":[{"href":"https:\/\/nanomicronspheres.com\/zh\/wp-json\/wp\/v2\/media?parent=2346"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nanomicronspheres.com\/zh\/wp-json\/wp\/v2\/categories?post=2346"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nanomicronspheres.com\/zh\/wp-json\/wp\/v2\/tags?post=2346"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}