Products
SHBC provides colored microspheres, fluorescent microspheres, magnetic beads, silica microspheres, chromatography packing microspheres and biological reagents for diagnostic assay development, nucleic acid extraction, protein purification and separation applications.
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PS/DVB10UM-100A
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SHBC
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10µm
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5g 10g 50g 100g 1000g
10µm Porous PS/DVB Microspheres with 100Å Pores
SHBC PS/DVB10UM-100A is a porous crosslinked polystyrene-divinylbenzene microsphere with a nominal particle size of 10µm and a pore size of 100Å.
The rigid polymer structure, hydrophobic surface and controlled pore system make it suitable for reversed-phase chromatography, preparative separation and custom stationary-phase development.
Product Overview
PS/DVB10UM-100A consists of porous polystyrene microspheres crosslinked with divinylbenzene.
The 10µm particle size provides convenient column packing and relatively low operating backpressure. The 100Å pores provide accessible internal surface area for small molecules, peptides and selected oligonucleotide applications.
The product is supplied as bulk porous microsphere packing media for research, method development and industrial chromatography.
Key Features and Benefits
Nominal particle size of 10µm
Controlled pore size of 100Å
Fully porous PS/DVB structure
Crosslinked polymer matrix
Hydrophobic stationary-phase surface
Good particle rigidity
High accessible internal surface area
Suitable for preparative chromatography
Suitable for small molecules and peptides
Compatible with surface modification
Custom pore sizes available
Laboratory and bulk supply supported
Product Specifications
Parameter | Specification |
|---|---|
Product Name | Porous Crosslinked PS/DVB Microspheres |
Catalog Number | PS/DVB10UM-100A |
Brand | SHBC |
Particle Size | 10µm |
Pore Size | 100Å |
Matrix | Polystyrene/Divinylbenzene |
Particle Structure | Porous and crosslinked |
Standard Surface | Hydrophobic |
Product Form | Bulk chromatography packing media |
Manufacturer | Shanghai SanYu Biotechnology Co., Ltd. |
Intended Use | Research and industrial chromatography |
Particle-size distribution, pore volume, specific surface area, crosslinking degree and pressure resistance are available according to the confirmed product specification.
Why Choose a 100Å Pore Size
The 100Å pore structure provides internal surface area for chromatographic interaction while maintaining good mass transfer for relatively small analytes.
It is suitable for developing separation methods involving:
Pharmaceutical compounds
Organic molecules
Peptides
Steroids
Vitamins
Antibiotics
Oligonucleotides
Selected protein fragments
For large intact proteins, antibodies or biomolecular complexes, a larger pore size may provide better pore accessibility.
Recommended Applications
Reversed-Phase Chromatography
The hydrophobic PS/DVB surface provides reversed-phase retention without requiring a conventional bonded C18 layer.
Pharmaceutical Separation
Suitable for method development and purification of active pharmaceutical ingredients, intermediates and related impurities.
Peptide Purification
Can be evaluated for analytical or preparative separation of synthetic peptides and peptide-related impurities.
Oligonucleotide Analysis
Suitable for custom method development involving DNA or RNA oligonucleotides under optimized mobile-phase conditions.
Antibiotic Separation
The hydrophobic polymer surface can retain antibiotics and other organic compounds with suitable chromatographic properties.
Small-Molecule Analysis
Suitable for organic acids, aromatic compounds, vitamins, steroids, herbicides and other small molecules.
Sample Preparation Media
Can be developed as a porous polymer adsorbent for solid-phase extraction and sample-cleanup applications.
Custom Stationary-Phase Development
The PS/DVB matrix can be chemically modified to create ion exchange, mixed-mode, hydrophilic or application-specific chromatography media.
Advantages of Crosslinked PS/DVB
Stable Polymer Matrix
Divinylbenzene crosslinking improves particle rigidity and helps maintain the porous structure during packing and chromatography operation.
Hydrophobic Retention
The polystyrene matrix provides inherent hydrophobic interaction for reversed-phase separation.
No Residual Silanol Groups
Unlike silica-based materials, PS/DVB does not contain residual silanol groups that may interact with basic analytes.
Flexible Mobile-Phase Selection
The polymer matrix can be evaluated with aqueous and organic mobile phases according to the validated method.
Good Loading Potential
The porous structure provides internal surface area for analyte retention and preparative purification.
Surface Modification Capability
The aromatic polymer structure can be further modified with charged, polar or reactive functional groups.
Benefits of the 10µm Particle Size
The 10µm particle size provides a practical balance between separation efficiency, column pressure and processing capacity.
Compared with smaller HPLC particles, 10µm microspheres generally generate lower backpressure and are convenient for:
Preparative chromatography
Semi-preparative chromatography
Larger-diameter columns
Process-development columns
Sample-cleanup cartridges
Bulk purification systems
Final column performance depends on particle-size distribution, packing quality, column dimensions and operating conditions.
Chromatography Packing Applications
PS/DVB10UM-100A can be used for packing:
Analytical HPLC columns
Semi-preparative columns
Preparative HPLC columns
Peptide purification columns
Pharmaceutical separation columns
Oligonucleotide research columns
Solid-phase extraction cartridges
Custom process columns
This product is supplied as bulk packing media unless a prepacked column is specifically requested.
General Column Packing Guidance
Select a compatible slurry solvent.
Fully disperse the microspheres before packing.
Prepare a uniform slurry without visible aggregates.
Transfer the slurry into the packing reservoir.
Pack the column using controlled flow or pressure.
Avoid exceeding the validated pressure limit.
Flush the column with the selected mobile phase.
Equilibrate until pressure and baseline are stable.
Test column efficiency with a suitable standard.
Confirm peak shape and retention reproducibility.
Packing conditions should be optimized for the column diameter, bed length, hardware and intended separation method.
Why Choose SHBC
Controlled Particle Production
SHBC applies controlled polymerization and particle-classification processes to support consistent particle size and morphology.
Controlled Porous Structure
The 100Å pore system is designed for chromatography applications involving small molecules, peptides and selected oligonucleotides.
Reliable Batch Consistency
Particle size, pore structure and polymer properties are controlled to support reproducible column performance.
Flexible Customization
Particle size, pore size, crosslinking degree, surface chemistry and packaging quantity can be customized.
Scale-Up Manufacturing
SHBC supports laboratory testing, pilot-scale column development and industrial batch production.
Technical Support
Technical assistance is available for particle selection, slurry preparation, column packing and stationary-phase development.
Custom and Bulk Supply
Shanghai SanYu Biotechnology Co., Ltd. supplies porous PS/DVB microspheres to pharmaceutical companies, chromatography manufacturers, research institutions and purification-process developers.
Available customization includes:
Custom particle size
Custom pore size
Custom pore volume
Custom specific surface area
Custom crosslinking degree
Surface functionalization
Alternative product forms
Custom packaging
OEM and ODM production
Batch quality documentation
Please provide the target analyte, chromatography mode, column dimensions and estimated order quantity when requesting a quotation.
Frequently Asked Questions
What is PS/DVB10UM-100A?
It is a porous crosslinked PS/DVB chromatography microsphere with a nominal particle size of 10µm and a pore size of 100Å.
What does 100Å mean?
It refers to the nominal diameter of the pores inside the porous polymer particles.
What analytes are suitable for 100Å pores?
Typical applications include small organic molecules, pharmaceuticals, peptides, steroids, vitamins and selected oligonucleotides.
Is it suitable for intact antibodies?
A larger pore size is normally preferred for intact antibodies and other large biomolecules.
Is the standard surface hydrophobic?
Yes. The standard polystyrene-divinylbenzene matrix has an inherently hydrophobic surface.
Can it be used for reversed-phase chromatography?
Yes. The hydrophobic polymer matrix can function as a reversed-phase stationary-phase material.
What is the advantage of 10µm particles?
The larger particles provide convenient packing and relatively low backpressure for preparative and process-scale columns.
Is this a finished chromatography column?
No. PS/DVB10UM-100A is supplied as bulk microsphere packing media unless a prepacked column is ordered.
Can SHBC customize the pore size?
Yes. Particle size, pore size, crosslinking degree and surface chemistry can be customized.
Is bulk manufacturing available?
Yes. SHBC supports samples, pilot quantities and bulk production.
Storage and Handling
Store PS/DVB10UM-100A according to the SHBC technical documentation.
Keep the product tightly sealed and protected from contamination. Avoid exposure to unvalidated solvents, temperatures or pressures. Follow appropriate safety procedures when handling dry polymer particles.
Request a Sample or Quotation
Contact Shanghai SanYu Biotechnology Co., Ltd. for samples, technical documentation, customized specifications or bulk pricing.
Product: 10µm Porous Crosslinked PS/DVB Microspheres
Catalog Number: PS/DVB10UM-100A
Brand: SHBC
Particle Size: 10µm
Pore Size: 100Å
Matrix: Polystyrene/Divinylbenzene
Manufacturer: Shanghai SanYu Biotechnology Co., Ltd.
For research and industrial chromatography use only.