Fmoc-Gln(Trt)-Wang Resin CAS 132327-80-1 0.3~0.8 Mmol/g, 100~200 Mesh, 1% DVB

Fmoc-Gln(Trt)-Wang Resin for C-Terminal Glutamine Peptides

SHBC Fmoc-Gln(Trt)-Wang Resin is a preloaded solid support for Fmoc solid-phase peptide synthesis of peptide acids containing C-terminal L-glutamine.

The resin contains N-alpha-Fmoc-N-delta-trityl-L-glutamine attached to an acid-labile Wang linker. The Trt group protects the glutamine side-chain amide during peptide assembly.

Acidic cleavage releases a peptide with C-terminal L-glutamine and removes the Trt protecting group.

Product Specifications

Key Advantages of SHBC Fmoc-Gln(Trt)-Wang Resin

Ready-to-Use Preloaded Support

Fmoc-Gln(Trt) is already attached to the Wang linker, eliminating the initial amino acid loading step.

Produces C-Terminal Glutamine Peptide Acids

Cleavage from the Wang linker releases peptides ending in L-glutamine with a free C-terminal carboxylic acid.

Trt-Protected Side-Chain Amide

Trt protects the glutamine side-chain amide during resin preparation and peptide-chain assembly, helping reduce unwanted side reactions.

Compatible with Fmoc SPPS

The resin supports standard Fmoc deprotection and amino acid coupling cycles used in manual and automated peptide synthesis.

Flexible Loading Range

A loading range of 0.3–0.8 mmol/g supports different peptide lengths, sequence properties and production scales.

Practical Resin Handling

The 1% DVB polystyrene matrix and 100–200 mesh particle size provide useful swelling, reagent accessibility, filtration and washing performance.

How Fmoc-Gln(Trt)-Wang Resin Works

Fmoc-Gln(Trt) is attached to the Wang linker through its alpha-carboxyl group. The amino group is protected by Fmoc, while the side-chain amide is protected by Trt.

A general synthesis workflow includes:

1. Pre-swell the resin in a compatible SPPS solvent.

2. Remove the Fmoc protecting group.

3. Couple the next protected amino acid.

4. Repeat Fmoc deprotection and coupling cycles.

5. Wash the resin between reaction steps.

6. Cleave and deprotect the completed peptide under validated acidic conditions.

7. Purify and characterize the resulting peptide acid.

Cleavage conditions should be optimized for the peptide sequence, protecting groups and synthesis scale.

Applications

SHBC Fmoc-Gln(Trt)-Wang Resin can be used for:

• Fmoc solid-phase peptide synthesis

• Peptides with C-terminal glutamine

• C-terminal peptide acid preparation

• Therapeutic peptide research

• Antigenic and epitope peptides

• Enzyme substrate peptides

• Peptide reference standards

• Biochemical research peptides

• Modified and labeled peptides

• Peptide library synthesis

• Process development

• Research-scale and batch peptide production

Choosing the Right Resin Loading

Resin loading influences synthesis capacity, reagent diffusion and aggregation risk.

Lower loading may be preferred for:

• Long peptide sequences

• Hydrophobic peptides

• Aggregation-prone sequences

• Sterically demanding modifications

• Complex peptide structures

Higher loading may improve productivity for shorter and less demanding sequences.

Select loading according to peptide length, sequence hydrophobicity, synthesis scale and purification requirements.

Comparison with Other SPPS Supports

Choose Fmoc-Gln(Trt)-Wang Resin when the required product is a peptide acid ending in L-glutamine.

Product Identification and CAS Clarification

Fmoc-Gln(Trt)-Wang Resin is a polymer-bound product identified by its complete product name, loading, particle size, DVB crosslinking and lot documentation.

CAS 132327-80-1 identifies free Fmoc-Gln(Trt)-OH. It is not a unique CAS number for the preloaded Wang resin.

Refer to the SHBC product label, COA and SDS for purchasing and technical identification.

Quality Control and Storage

Important qualification parameters include:

• Fmoc loading or substitution

• Amino acid identity

• Trt protection integrity

• Enantiomeric purity

• Dipeptide content

• Particle-size distribution

• DVB crosslinking

• Moisture content

• Resin swelling performance

• Residual unreacted linker sites

• Test coupling and cleavage performance

• Lot-to-lot consistency

Request the lot-specific SHBC COA for available test results.

Keep the resin tightly sealed in a cool, dry place according to the product label and SDS. Pre-swell the resin completely before use.

Frequently Asked Questions

What is Fmoc-Gln(Trt)-Wang Resin used for?

It is used in Fmoc SPPS to prepare peptide acids containing C-terminal L-glutamine.

What C-terminus is obtained after cleavage?

Validated acidic cleavage releases a peptide with C-terminal L-Gln-COOH.

What does the Trt group protect?

Trt protects the glutamine side-chain amide during peptide synthesis.

Is the Trt group removed during cleavage?

Yes. Trt is normally removed together with peptide cleavage under validated acidic conditions.

Is the first amino acid already loaded?

Yes. Fmoc-Gln(Trt) is preloaded onto the Wang linker, allowing synthesis to begin with Fmoc removal.

What is the difference between glutamine and asparagine resin?

Fmoc-Gln(Trt)-Wang Resin produces peptides ending in glutamine, while Fmoc-Asn(Trt)-Wang Resin produces peptides ending in asparagine.

Is CAS 132327-80-1 the CAS number of this resin?

No. CAS 132327-80-1 identifies free Fmoc-Gln(Trt)-OH, not the polymer-bound Wang resin.

What loading should I choose?

Lower loading is commonly considered for long, hydrophobic or aggregation-prone peptides. Higher loading may improve productivity for shorter sequences.

What information is required for a quotation?

Please provide the required quantity, target loading, peptide length, synthesis scale, packaging and required quality documents.

Request a Sample or Bulk Quote

SHBC supplies Fmoc-Gln(Trt)-Wang Resin for Fmoc peptide synthesis, process development and batch production.

Contact Shanghai SanYu Biotechnology Co., Ltd. to request samples, bulk pricing, loading options, packaging information, COA and SDS.

For research and process-development use unless otherwise specified.