Fmoc-Glu(OtBu)-Wang Resin CAS109745-15-5 0.3~0.8 Mmol/g, 100~200 Mesh, 1% DVB

Fmoc-Glu(OtBu)-Wang Resin for C-Terminal Glutamic Acid Peptides

SHBC Fmoc-Glu(OtBu)-Wang Resin is a preloaded solid support for Fmoc solid-phase peptide synthesis of peptide acids containing C-terminal L-glutamic acid.

The resin contains N-Fmoc-L-glutamic acid gamma-tert-butyl ester attached to an acid-labile Wang linker. The OtBu group protects the side-chain carboxyl group during peptide assembly.

Acidic cleavage releases a peptide with C-terminal L-glutamic acid and removes the OtBu protecting group.

Product Specifications

Key Advantages of SHBC Fmoc-Glu(OtBu)-Wang Resin

Ready-to-Use Preloaded Support

Fmoc-Glu(OtBu) is already attached to the Wang linker, eliminating the initial amino acid loading step.

Produces C-Terminal Glutamic Acid Peptides

Cleavage from the Wang linker releases peptide acids ending in L-glutamic acid.

Protected Side-Chain Carboxyl Group

The OtBu group protects the gamma-carboxyl group during Fmoc deprotection and amino acid coupling cycles.

Compatible with Fmoc SPPS

The resin supports standard Fmoc deprotection and coupling procedures used in manual and automated peptide synthesis.

Flexible Loading Range

A loading range of 0.3–0.8 mmol/g supports different peptide lengths, sequence properties and production scales.

Practical Resin Handling

The 1% DVB polystyrene matrix and 100–200 mesh particle size provide useful swelling, reagent access, filtration and washing performance.

How Fmoc-Glu(OtBu)-Wang Resin Works

Fmoc-L-Glu(OtBu) is attached to the Wang linker through its alpha-carboxyl group. Its gamma-carboxyl group remains protected as an OtBu ester during peptide synthesis.

A general synthesis workflow includes:

1. Pre-swell the resin in a compatible SPPS solvent.

2. Remove the Fmoc protecting group.

3. Couple the next protected amino acid.

4. Repeat Fmoc deprotection and coupling cycles.

5. Wash the resin between reaction steps.

6. Cleave and deprotect the completed peptide under validated acidic conditions.

7. Purify and characterize the resulting peptide acid.

Acidic cleavage releases the peptide from the Wang linker and removes the OtBu side-chain protection.

Applications

SHBC Fmoc-Glu(OtBu)-Wang Resin can be used for:

• Fmoc solid-phase peptide synthesis

• Peptides with C-terminal glutamic acid

• C-terminal peptide acid preparation

• Therapeutic peptide research

• Antigenic and epitope peptides

• Enzyme substrate peptides

• Peptide reference standards

• Biochemical research peptides

• Modified and labeled peptides

• Peptide library synthesis

• Process development

• Research-scale and batch peptide production

Choosing the Right Resin Loading

Resin loading affects theoretical synthesis capacity, reagent diffusion and aggregation risk.

Lower loading may be preferred for:

• Long peptide sequences

• Hydrophobic peptides

• Aggregation-prone sequences

• Sterically demanding modifications

• Complex peptide structures

Higher loading may improve productivity for shorter and less demanding sequences.

Select the loading according to peptide length, sequence hydrophobicity, synthesis scale and purification requirements.

Comparison with Other SPPS Supports

Choose Fmoc-Glu(OtBu)-Wang Resin when the required product is a peptide acid ending in L-glutamic acid.

Product Identification and CAS Clarification

Fmoc-Glu(OtBu)-Wang Resin is a polymer-bound L-amino acid product identified by its complete product name, loading, particle size, crosslinking and lot documentation.

CAS 109745-15-5 identifies free Fmoc-D-Glu-OtBu, specifically an alpha-tert-butyl ester of D-glutamic acid. It does not identify the L-Glu(OtBu)-Wang Resin described on this page.

The two products differ in:

• L versus D configuration

• Polymer-bound versus soluble form

• Gamma- versus alpha-carboxyl protection

• Intended SPPS application

Refer to the SHBC product label, COA and SDS for purchasing and technical identification.

Quality Control and Storage

Important qualification parameters include:

• Fmoc loading or substitution

• Amino acid identity

• OtBu protection integrity

• Enantiomeric purity

• Dipeptide content

• Particle-size distribution

• DVB crosslinking

• Moisture content

• Resin swelling performance

• Residual unreacted linker sites

• Test coupling and cleavage performance

• Lot-to-lot consistency

Request the lot-specific SHBC COA for available test results.

Keep the resin tightly sealed in a cool, dry place according to the product label and SDS. Pre-swell the resin completely before use.

Frequently Asked Questions

What is Fmoc-Glu(OtBu)-Wang Resin used for?

It is used in Fmoc SPPS to prepare peptide acids containing C-terminal L-glutamic acid.

What C-terminus is obtained after cleavage?

Validated acidic cleavage releases a peptide with C-terminal L-Glu-COOH.

What does the OtBu group protect?

OtBu protects the glutamic acid gamma-carboxyl group during peptide synthesis.

Is the OtBu group removed during cleavage?

Yes. OtBu is normally removed together with peptide cleavage under validated acidic conditions.

Is the first amino acid already loaded?

Yes. Fmoc-L-Glu(OtBu) is preloaded onto the Wang linker, allowing synthesis to begin with Fmoc removal.

What is the difference between glutamic acid and glutamine resin?

Fmoc-Glu(OtBu)-Wang Resin produces peptides ending in glutamic acid with a side-chain carboxyl group. Fmoc-Gln(Trt)-Wang Resin produces peptides ending in glutamine with a side-chain amide.

Is CAS 109745-15-5 the CAS number of this resin?

No. CAS 109745-15-5 identifies free Fmoc-D-Glu-OtBu, not the polymer-bound L-Glu(OtBu)-Wang Resin.

What loading should I choose?

Lower loading is commonly considered for long, hydrophobic or aggregation-prone peptides. Higher loading may improve productivity for shorter sequences.

What information is required for a quotation?

Please provide the required quantity, target loading, peptide length, synthesis scale, packaging and required quality documents.

Request a Sample or Bulk Quote

SHBC supplies Fmoc-Glu(OtBu)-Wang Resin for Fmoc peptide synthesis, process development and batch production.

Contact Shanghai SanYu Biotechnology Co., Ltd. to request samples, bulk pricing, loading options, packaging information, COA and SDS.

For research and process-development use unless otherwise specified.