Fmoc-Gly-Wang Resin CAS 29022-11-5 0.3~0.8mmol/g,100~200 Mesh, 1% DVB

Fmoc-Gly-Wang Resin for C-Terminal Glycine Peptides

SHBC Fmoc-Gly-Wang Resin is a preloaded solid support for Fmoc solid-phase peptide synthesis of peptide acids containing C-terminal glycine.

Fmoc-glycine is attached to an acid-labile Wang linker on a 1% DVB-crosslinked polystyrene matrix. After peptide assembly, acidic cleavage releases a peptide with a free C-terminal Gly-COOH group.

The resin is suitable for manual, automated, research-scale and batch peptide synthesis.

Product Specifications

Key Advantages of SHBC Fmoc-Gly-Wang Resin

Ready-to-Use Preloaded Support

Fmoc-glycine is already attached to the Wang linker, eliminating the initial amino acid loading step.

Produces C-Terminal Glycine Peptide Acids

Acidic cleavage releases peptide acids ending in glycine with a free C-terminal carboxyl group.

No Side-Chain Protection Required

Glycine has no functional side chain, simplifying protecting-group selection and cleavage.

No Chiral Center

Glycine is the only standard amino acid without a stereogenic center, removing concerns about glycine enantiomerization.

Flexible Loading Range

A loading range of 0.3–0.8 mmol/g supports different peptide lengths, sequence characteristics and production scales.

Practical Resin Handling

The 1% DVB polystyrene matrix and 100–200 mesh particle size provide useful swelling, reagent accessibility, filtration and washing performance.

How Fmoc-Gly-Wang Resin Works

Fmoc-glycine is attached to the Wang linker through its carboxyl group. The Fmoc group protects the amino functionality before synthesis.

A general synthesis workflow includes:

1. Pre-swell the resin in a compatible SPPS solvent.

2. Remove the Fmoc protecting group.

3. Couple the next protected amino acid.

4. Repeat Fmoc deprotection and coupling cycles.

5. Wash the resin between reaction steps.

6. Cleave the completed peptide under validated acidic conditions.

7. Purify and characterize the resulting peptide acid.

Cleavage conditions should be selected according to the peptide sequence and side-chain protecting groups.

Applications

SHBC Fmoc-Gly-Wang Resin can be used for:

• Fmoc solid-phase peptide synthesis

• Peptides with C-terminal glycine

• C-terminal peptide acid preparation

• Flexible peptide linker sequences

• Antigenic and epitope peptides

• Enzyme substrate peptides

• Peptide reference standards

• Biochemical research peptides

• Modified and labeled peptides

• Peptide library synthesis

• Therapeutic peptide research

• Process development

• Research-scale and batch peptide production

Choosing the Right Resin Loading

Resin loading affects synthesis capacity, reagent diffusion and peptide aggregation.

Lower loading may be preferred for:

• Long peptide sequences

• Hydrophobic peptides

• Aggregation-prone sequences

• Sterically demanding modifications

• Complex peptide structures

Higher loading may improve batch productivity for shorter and less demanding sequences.

Select loading according to peptide length, sequence hydrophobicity, synthesis scale and purification requirements.

Comparison with Other SPPS Supports

Choose Fmoc-Gly-Wang Resin when the required product is a peptide acid ending in glycine.

Product Identification and CAS Clarification

Fmoc-Gly-Wang Resin is a polymer-bound product identified by its complete product name, loading, particle size, DVB crosslinking and lot documentation.

CAS 29022-11-5 identifies free Fmoc-Gly-OH. It is not a unique identifier for the preloaded Fmoc-Gly-Wang Resin.

Refer to the SHBC product label, COA and SDS for purchasing and technical identification.

Quality Control and Storage

Important qualification parameters include:

• Fmoc loading or substitution

• Preloaded amino acid identity

• Dipeptide content

• Particle-size distribution

• DVB crosslinking

• Moisture content

• Resin swelling performance

• Residual unreacted linker sites

• Test coupling efficiency

• Test cleavage performance

• Filtration behavior

• Lot-to-lot consistency

Request the lot-specific SHBC COA for available test results.

Keep the resin tightly sealed in a cool, dry place according to the product label and SDS. Pre-swell the resin completely before use.

Frequently Asked Questions

What is Fmoc-Gly-Wang Resin used for?

It is used in Fmoc SPPS to prepare peptide acids containing C-terminal glycine.

What C-terminus is obtained after cleavage?

Validated acidic cleavage releases a peptide with a free C-terminal Gly-COOH group.

Does glycine require side-chain protection?

No. Glycine does not contain a functional side chain requiring protection.

Is glycine chiral?

No. Glycine has no stereogenic center.

Is the first amino acid already loaded?

Yes. Fmoc-glycine is preloaded onto the Wang linker, allowing synthesis to begin with Fmoc removal.

What is the difference between Fmoc-Gly-Wang and Fmoc-Gly-Rink Amide Resin?

Fmoc-Gly-Wang Resin produces C-terminal glycine peptide acids. Fmoc-Gly-Rink Amide Resin produces C-terminal glycine peptide amides.

Is CAS 29022-11-5 the CAS number of this resin?

No. CAS 29022-11-5 identifies free Fmoc-Gly-OH, not the polymer-bound Wang resin.

What loading should I choose?

Lower loading is commonly considered for long, hydrophobic or aggregation-prone peptides. Higher loading may improve productivity for shorter sequences.

What information is required for a quotation?

Please provide the required quantity, target loading, peptide length, synthesis scale, packaging and required quality documents.

Request a Sample or Bulk Quote

SHBC supplies Fmoc-Gly-Wang Resin for Fmoc peptide synthesis, process development and batch production.

Contact Shanghai SanYu Biotechnology Co., Ltd. to request samples, bulk pricing, loading options, packaging information, COA and SDS.

For research and process-development use unless otherwise specified.