Fmoc-Gly-Wang Resin CAS 65307-53-1 100-200mesh,1% DVB

Fmoc-Gly-Wang Resin for C-Terminal Glycine Peptides

SHBC Fmoc-Gly-Wang Resin is a glycine-preloaded solid support for Fmoc solid-phase peptide synthesis (SPPS).

Fmoc-protected glycine is attached to an acid-labile Wang linker on a 1% DVB-crosslinked polystyrene matrix. After peptide assembly and acidic cleavage, the resin produces a peptide containing C-terminal glycine with a free carboxylic acid.

The 100–200 mesh particle size provides practical swelling, reagent accessibility, filtration and washing performance.

Product Specifications

Key Advantages of SHBC Fmoc-Gly-Wang Resin

Ready-to-Use Preloaded Support

Glycine is already attached to the Wang linker, eliminating the initial amino acid loading step and simplifying peptide synthesis setup.

Defined C-Terminal Glycine

The resin is designed for peptides that require glycine as the C-terminal amino acid and a free carboxyl group after cleavage.

No Glycine Stereochemistry Concern

Glycine has no chiral side chain, avoiding racemization concerns associated with loading chiral C-terminal amino acids.

Compatible with Fmoc SPPS

The Wang linkage remains stable during standard base-mediated Fmoc deprotection and amino acid coupling cycles.

Acid-Labile Peptide Release

The completed peptide can be cleaved using a validated TFA-based system, normally together with side-chain deprotection.

Practical Polystyrene Matrix

The 1% DVB-crosslinked matrix and 100–200 mesh size provide a useful balance between swelling, reagent diffusion, filtration and mechanical handling.

How Fmoc-Gly-Wang Resin Works

Fmoc-Gly-Wang Resin contains the protected C-terminal glycine already attached to the solid support.

A typical synthesis workflow includes:

1. Pre-swell the resin in a compatible SPPS solvent.

2. Remove the Fmoc group from resin-bound glycine.

3. Couple the next protected amino acid in the sequence.

4. Continue repeated Fmoc deprotection and coupling cycles.

5. Wash the resin between reaction steps.

6. Cleave and deprotect the completed peptide using validated acidic conditions.

7. Purify and characterize the resulting C-terminal glycine peptide acid.

Reaction conditions should be optimized according to the peptide sequence, resin loading and synthesis scale.

Applications

SHBC Fmoc-Gly-Wang Resin can be used for:

• Fmoc solid-phase peptide synthesis

• C-terminal glycine peptide synthesis

• Peptide acids

• Glycine-containing peptide fragments

• Therapeutic peptide research

• Antigenic and epitope peptides

• Enzyme substrate peptides

• Peptide reference standards

• Peptide library synthesis

• Modified and labeled peptides

• Linker- or spacer-containing peptides

• Peptidomimetic research

• Bioconjugation intermediate preparation

• Research-scale and batch peptide production

The resin is especially useful when glycine is the predetermined C-terminal residue of the target peptide.

Selecting the Right Resin Loading

Resin loading affects theoretical capacity, reagent accessibility and peptide aggregation.

Lower loading may be preferred for:

• Long peptide sequences

• Hydrophobic peptides

• Branched peptides

• Aggregation-prone sequences

• Sterically demanding coupling reactions

Higher loading may improve productivity for shorter and less demanding peptides.

When requesting a quotation, specify the target loading range. Actual substitution should be confirmed using the lot-specific Certificate of Analysis.

Fmoc-Gly-Wang Resin vs Other SPPS Resins

Choose Fmoc-Gly-Wang Resin when the target peptide requires a C-terminal glycine carboxylic acid and a ready-to-use preloaded support.

Quality Control and Handling

Recommended qualification parameters include:

• Glycine loading or substitution

• Fmoc content

• Particle-size distribution

• DVB crosslinking percentage

• Moisture content

• Residual free linker sites

• Swelling performance

• Fmoc deprotection response

• Test coupling efficiency

• Cleavage performance

• Lot-to-lot consistency

Keep the resin tightly sealed in a cool, dry environment according to the product label and SDS. Pre-swell the resin completely before use and protect it from moisture and contamination.

Frequently Asked Questions

What is Fmoc-Gly-Wang Resin?

It is a Wang-type polystyrene resin preloaded with Fmoc-protected glycine for Fmoc solid-phase peptide synthesis.

What C-terminus is produced after cleavage?

The final peptide contains a C-terminal glycine with a free carboxylic acid group.

Does glycine need to be loaded before synthesis?

No. Glycine is already attached to the Wang linker. Synthesis begins with Fmoc removal followed by coupling of the next amino acid.

Is the resin compatible with automated peptide synthesizers?

Yes. It can be used with compatible automated Fmoc-SPPS workflows after method optimization.

How is the peptide cleaved from Wang Resin?

A validated TFA-based cleavage system is commonly used. The exact acid concentration, scavengers and reaction time depend on the peptide sequence and protecting groups.

What is the difference between Fmoc-Gly-Wang Resin and Rink Amide Resin?

Fmoc-Gly-Wang Resin produces a C-terminal glycine carboxylic acid. Rink Amide Resin produces a C-terminal primary amide.

Why should loading be confirmed by COA?

Loading can vary between product grades and manufacturing lots. The lot-specific value is required for accurate resin weighing and reagent calculations.

What information is required for a quotation?

Please provide the required quantity, target loading, peptide application, packaging requirement and required technical documents.

Request a Sample or Bulk Quote

SHBC supplies Fmoc-Gly-Wang Resin for Fmoc peptide synthesis, process development and batch production.

Contact Shanghai SanYu Biotechnology Co., Ltd. to request evaluation quantities, bulk packaging, lot-specific loading data, COA, SDS and quotation details.

For research and process-development use unless otherwise specified.