Fmoc-Lys(Boc)-Wang Resin CAS71989-26-9 0.3~0.8mmol/g, 100~200 Mesh, 1% DVB

Fmoc-Lys(Boc)-Wang Resin for C-Terminal Lysine Peptides

SHBC Fmoc-Lys(Boc)-Wang Resin is a preloaded solid support for Fmoc solid-phase peptide synthesis of peptide acids containing C-terminal L-lysine.

The resin contains N-alpha-Fmoc-N-epsilon-Boc-L-lysine attached to an acid-labile Wang linker on a 1% DVB-crosslinked polystyrene matrix.

The Fmoc group protects the alpha-amino group, while Boc protects the lysine epsilon-amino side chain during peptide assembly. Acidic cleavage releases the peptide as C-terminal L-Lys-OH and removes the Boc group.

Product Specifications

Key Advantages of SHBC Fmoc-Lys(Boc)-Wang Resin

Ready-to-Use Preloaded Support

Fmoc-Lys(Boc)-OH is already attached to the Wang linker, eliminating the separate first amino acid loading step.

Produces C-Terminal Lysine Peptide Acids

Acidic cleavage releases a peptide containing C-terminal L-Lys-OH without requiring additional solution-phase conversion.

Boc-Protected Lysine Side Chain

The Boc group protects the epsilon-amino group during repeated Fmoc deprotection and amino acid coupling cycles.

Compatible with Fmoc SPPS

The resin supports standard manual and automated Fmoc peptide synthesis workflows.

Flexible Loading Range

The 0.3–0.8 mmol/g loading range allows users to balance synthesis capacity, reagent accessibility and aggregation control.

Practical Resin Handling

The 100–200 mesh, 1% DVB polystyrene matrix supports useful swelling, reagent diffusion, washing and filtration in compatible SPPS solvents.

How Fmoc and Boc Protection Works

Fmoc-Lys(Boc)-OH is attached to the Wang linker through an acid-labile ester bond. The preloaded lysine becomes the C-terminal residue of the peptide.

During synthesis:

1. The resin is pre-swelled in a compatible solvent.

2. The alpha-amino Fmoc group is removed.

3. The next protected amino acid is coupled.

4. Fmoc deprotection and coupling cycles are repeated.

5. The Boc group remains on the lysine side chain during base-mediated Fmoc removal.

6. The completed peptide is cleaved under validated acidic conditions.

7. Acidic cleavage normally removes Boc and releases the peptide as Lys-OH.

The final product contains a C-terminal carboxylic acid and a free lysine epsilon-amino group unless another modification strategy is used.

Applications

SHBC Fmoc-Lys(Boc)-Wang Resin can be used for:

• C-terminal lysine peptide synthesis

• Fmoc solid-phase peptide synthesis

• Peptide acid preparation

• Lysine-rich and cationic peptide research

• Antigenic and epitope peptide production

• Enzyme substrate peptides

• Protein fragment synthesis

• Peptide structure–activity studies

• Peptide library preparation

• Modified and labeled peptides

• Conjugation-ready peptide research

• Peptide reference standards

• Therapeutic peptide research

• Process development and batch production

The free lysine side-chain amino group obtained after cleavage can provide a functional site for subsequent labeling or conjugation when required by the peptide design.

Choosing the Right Resin Loading

Resin loading affects theoretical production capacity, coupling accessibility and aggregation risk.

Lower loading may be preferred for:

• Long peptide sequences

• Lysine-rich or highly charged peptides

• Aggregation-prone sequences

• Sterically demanding couplings

• Branched or heavily modified peptides

Higher loading may provide greater batch productivity for shorter and less demanding sequences.

Pilot-scale synthesis is recommended before transferring the process to larger batches.

Comparison with Other Lysine SPPS Supports

Choose Fmoc-Lys(Boc)-Wang Resin when the target peptide requires a C-terminal L-lysine carboxylic acid and standard acid-removable side-chain protection.

Product Identification and CAS Clarification

CAS 71989-26-9 identifies the free amino acid derivative Fmoc-Lys(Boc)-OH. It is not a unique CAS number for polymer-bound Fmoc-Lys(Boc)-Wang Resin.

The preloaded resin should be identified using:

• Product name

• SHBC product or catalog number

• Loading range

• Particle size

• DVB crosslinking

• Lot number

• Certificate of Analysis

• Safety Data Sheet

Contact SHBC if product-specific identification documents are required for purchasing, customs or technical evaluation.

Quality Control and Storage

Recommended qualification parameters include:

• Fmoc amino acid loading

• Resin identity

• Boc protecting-group integrity

• Particle-size distribution

• DVB crosslinking

• Moisture content

• DMF swelling performance

• Enantiomeric purity

• D-lysine content

• Dipeptide content

• Test coupling performance

• Test cleavage performance

• Lot-to-lot consistency

Keep the resin tightly sealed in a cool, dry place according to the product label and SDS. Protect it from moisture, contamination and prolonged exposure to unsuitable conditions.

Pre-swell the resin completely before use.

Frequently Asked Questions

What is Fmoc-Lys(Boc)-Wang Resin used for?

It is used in Fmoc SPPS to synthesize peptide acids containing C-terminal L-lysine.

Is the first amino acid already loaded?

Yes. Fmoc-Lys(Boc)-OH is preloaded onto the Wang linker, reducing resin preparation steps.

What does the Boc group protect?

Boc protects the epsilon-amino side chain of lysine during peptide-chain assembly.

Is Boc stable during Fmoc deprotection?

Boc is normally stable under the basic conditions used for Fmoc removal.

Is Boc removed during peptide cleavage?

Yes. Boc is normally removed during validated acidic cleavage from the Wang resin.

What C-terminus is obtained after cleavage?

The resulting peptide normally contains a C-terminal L-lysine carboxylic acid, written as Lys-OH.

Can the lysine side chain be modified selectively during synthesis?

Boc is intended for removal during final acidic cleavage. An orthogonal protecting group such as Mtt or Alloc may be more suitable when selective on-resin side-chain modification is required.

Is this resin suitable for peptide amide synthesis?

No. Standard Fmoc-Lys(Boc)-Wang Resin produces a peptide acid. A Rink Amide-based support should be selected for peptide amides.

Is CAS 71989-26-9 the CAS number of the resin?

The CAS number identifies free Fmoc-Lys(Boc)-OH. Refer to the SHBC product number, COA and SDS for identification of the preloaded resin.

What information is required for a quotation?

Please provide the required quantity, target loading, peptide application, packaging requirements and required quality documents.

Request a Sample or Bulk Quote

SHBC supplies Fmoc-Lys(Boc)-Wang Resin for research, process development and batch peptide synthesis.

Contact Shanghai SanYu Biotechnology Co., Ltd. to discuss evaluation samples, loading requirements, bulk packaging, COA, SDS and quotation details.

For research and process-development use only unless otherwise specified.