Rink Amide MBHA Resin CAS 431041-83-7 100-200mesh，1%DVB

Rink Amide MBHA Resin for Fmoc Peptide Amide Synthesis

SHBC Rink Amide MBHA Resin is an acid-labile solid support designed for the Fmoc solid-phase peptide synthesis (SPPS) of peptides with a C-terminal primary amide.

The modified Rink Amide linker is attached through a norleucine spacer to an MBHA-functionalized, 1% DVB-crosslinked polystyrene matrix. The 100–200 mesh particle size provides practical swelling, reagent accessibility, filtration and washing performance.

This resin is suitable for research, process development and batch production of peptide amides.

Product Specifications

Key Advantages of SHBC Rink Amide MBHA Resin

Direct Production of Peptide Amides

Acidic cleavage releases the synthesized peptide with a C-terminal –CONH₂ group, eliminating the need for an additional amidation step.

Compatible with Fmoc SPPS

The resin supports standard Fmoc deprotection and amino acid coupling cycles used in manual and automated peptide synthesis.

Efficient Acidic Cleavage

The completed peptide can typically be cleaved using a validated TFA-based cleavage system with suitable scavengers.

Stable 1% DVB Polystyrene Matrix

The crosslinked polystyrene matrix provides mechanical stability while allowing useful swelling and reagent diffusion in compatible SPPS solvents.

Practical 100–200 Mesh Size

The selected particle size balances reaction accessibility, filtration speed, washing efficiency and batch handling.

Suitable for Different Synthesis Scales

SHBC Rink Amide MBHA Resin can support laboratory evaluation, peptide process development and larger batch synthesis.

How Rink Amide MBHA Resin Works

The resin contains an Fmoc-protected Rink Amide linker. After Fmoc removal, the exposed linker amine is coupled with the protected C-terminal amino acid.

A typical workflow includes:

1. Pre-swell the resin in a compatible SPPS solvent.

2. Remove the Fmoc protecting group from the linker.

3. Couple the protected C-terminal amino acid.

4. Continue repeated Fmoc deprotection and coupling cycles.

5. Wash the resin between each reaction step.

6. Cleave and deprotect the peptide using a validated acidic system.

7. Purify and characterize the resulting peptide amide.

Coupling and cleavage conditions should be optimized according to the peptide sequence, resin loading and synthesis scale.

Applications

SHBC Rink Amide MBHA Resin is suitable for:

• C-terminal peptide amide synthesis

• Fmoc solid-phase peptide synthesis

• Therapeutic peptide research

• Peptide hormone and neuropeptide synthesis

• Antigenic and epitope peptide production

• Enzyme substrate preparation

• Peptide drug discovery

• Peptide library synthesis

• Modified and labeled peptides

• Bioconjugation-ready peptides

• Immunoassay peptide standards

• Research-scale and batch peptide manufacturing

It is especially useful when a C-terminal amide is required for the peptide’s biological activity, stability or natural sequence structure.

Selecting the Right Resin Loading

Resin loading affects synthesis capacity, reagent accessibility and peptide aggregation.

Lower loading is often preferred for:

• Long peptide sequences

• Hydrophobic peptides

• Branched or sterically demanding peptides

• Aggregation-prone sequences

• Difficult coupling reactions

Higher loading may improve batch productivity for shorter and less demanding peptides.

Please specify the required loading range when requesting a quotation. Lot-specific substitution data should be confirmed through the Certificate of Analysis.

Rink Amide MBHA Resin vs Rink Amide AM Resin

Both resins produce C-terminal peptide amides. Resin architecture, loading and swelling performance should be evaluated for the intended peptide sequence and process.

Comparison with Other SPPS Resins

Choose Rink Amide MBHA Resin when the target product requires a C-terminal primary amide and standard Fmoc-SPPS processing.

Quality Control and Storage

Recommended qualification parameters include:

• Linker loading or substitution

• Particle-size distribution

• DVB crosslinking percentage

• Fmoc content

• Moisture content

• Swelling performance

• First amino acid coupling efficiency

• Test-cleavage performance

• Filtration and washing behavior

• Lot-to-lot consistency

Store the resin tightly sealed in a cool, dry environment according to the product label and SDS. Protect it from moisture, contamination and prolonged exposure to unsuitable conditions.

Frequently Asked Questions

What is Rink Amide MBHA Resin used for?

It is used in Fmoc solid-phase peptide synthesis to prepare peptides with a C-terminal primary amide.

What does MBHA mean?

MBHA refers to the methylbenzhydrylamine-based polystyrene support used in the resin structure.

What peptide C-terminus is obtained after cleavage?

Cleavage releases a peptide containing a C-terminal –CONH₂ group.

Is this resin compatible with Fmoc chemistry?

Yes. It is designed for Fmoc-based peptide-chain assembly.

What is the role of the norleucine spacer?

The norleucine spacer forms part of the connection between the modified Rink Amide linker and the MBHA support.

What is the typical cleavage method?

A TFA-based cleavage system with sequence-appropriate scavengers is commonly used. Conditions must be validated for the target peptide.

Is low-loading resin better for long peptides?

Lower loading may improve reagent access and reduce aggregation for long, hydrophobic or sterically demanding sequences.

What information is needed for a quotation?

Please provide the required quantity, target loading, peptide length, synthesis scale, packaging requirement and required quality documents.

Request a Sample or Bulk Quote

SHBC supplies Rink Amide MBHA Resin for Fmoc peptide amide synthesis, process development and batch production.

Contact Shanghai SanYu Biotechnology Co., Ltd. to request evaluation quantities, bulk packaging, lot-specific loading data, COA, SDS and quotation details.

For research and process-development use unless otherwise specified.