Products
SHBC provides colored microspheres, fluorescent microspheres, magnetic beads, silica microspheres, chromatography packing microspheres and biological reagents for diagnostic assay development, nucleic acid extraction, protein purification and separation applications.
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PM30UM-100A
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SHBC
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30µm
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5g 10g 50g 100g 1000g
30µm Porous Crosslinked PMMA Microspheres with 100Å Pores
SHBC PM30UM-100A is a porous crosslinked polymethyl methacrylate microsphere with a nominal particle size of 30µm and a pore size of 100Å.
The controlled particle size, porous structure and methacrylate polymer matrix make it suitable for low-pressure chromatography, small-molecule separation, peptide purification and custom separation-media development.
Product Overview
PM30UM-100A is manufactured from a crosslinked PMMA-based polymer matrix.
The 30µm particle size supports convenient column packing, good flow performance and lower operating pressure than smaller analytical particles. The 100Å pore structure provides internal surface area for the interaction and separation of relatively small analytes.
The product is supplied as bulk porous microsphere media for research, preparative purification and industrial process development.
Key Features and Benefits
Nominal particle size of 30µm
Controlled pore size of 100Å
Porous crosslinked PMMA matrix
Uniform spherical morphology
Good particle rigidity
Accessible internal pore structure
Low-pressure column compatibility
Suitable for small molecules and peptides
Alternative selectivity to PS/DVB media
Flexible surface functionalization
Laboratory and bulk supply
Custom specifications available
Product Specifications
Parameter | Specification |
|---|---|
Product Name | Porous Crosslinked PMMA Microspheres |
Catalog Number | PM30UM-100A |
Brand | SHBC |
Particle Size | 30µm |
Pore Size | 100Å |
Equivalent Pore Diameter | 10nm |
Matrix | Crosslinked PMMA |
Particle Structure | Porous spherical microspheres |
Standard Surface | Methacrylate polymer surface |
Product Form | Bulk separation and chromatography media |
Manufacturer | Shanghai SanYu Biotechnology Co., Ltd. |
Particle-size distribution, pore volume, surface area, crosslinking degree and supply form should be confirmed in the SHBC technical data sheet.
Benefits of 30µm Particles and 100Å Pores
Good Flow Performance
The 30µm particle size supports efficient liquid flow through low-pressure and preparative columns.
Lower Column Pressure
Larger particles generally create less flow resistance than smaller HPLC particles, making them suitable for preparative and process-scale systems.
Controlled Internal Surface
The 100Å pore structure provides internal surface area for adsorption and chromatographic interaction.
Suitable for Smaller Analytes
The pore structure can be evaluated for small organic molecules, pharmaceutical compounds, peptides and other relatively small analytes.
Easy Process Handling
The 30µm microspheres are convenient for slurry preparation, column packing, washing and recovery.
Recommended Applications
Small-Molecule Separation
Suitable for separation-method development involving organic compounds, pharmaceutical intermediates and related impurities.
Peptide Purification
Can be evaluated for analytical or preparative purification of peptides and peptide-related compounds.
Pharmaceutical Purification
Suitable for process research involving active ingredients, intermediates and hydrophobic or moderately polar impurities.
Natural Product Separation
Can be used for method development involving plant extracts, fermentation products and other complex mixtures.
Low-Pressure Chromatography
The 30µm particles are suitable for gravity-flow, low-pressure and preparative chromatography systems.
Solid-Phase Extraction
The porous PMMA matrix can be developed as a sorbent for sample cleanup, concentration and impurity removal.
Size Exclusion Media Development
The controlled porous structure can be evaluated as a base matrix for size-based separation after suitable surface treatment.
Functional Chromatography Resin
PM30UM-100A can be further modified to prepare ion exchange, affinity, hydrophobic interaction or mixed-mode chromatography media.
Advantages of the PMMA Matrix
Alternative Separation Selectivity
The methacrylate polymer surface provides different polarity and retention characteristics from highly hydrophobic PS/DVB materials.
Moderate Surface Polarity
PMMA may provide milder interaction for selected polar compounds, peptides and biomolecules.
No Silanol Groups
The polymer matrix does not contain the residual silanol groups associated with conventional silica-based packing materials.
Flexible Surface Modification
The porous matrix can be coated or functionalized with charged, reactive, hydrophilic or affinity groups.
Stable Crosslinked Structure
Crosslinking helps maintain particle shape and pore structure during packing, washing and separation processes.
PMMA vs. PS/DVB Microspheres
Feature | Porous PMMA | Porous PS/DVB |
|---|---|---|
Surface Character | Moderately polar | Strongly hydrophobic |
Retention Strength | Generally milder | Generally stronger |
Main Advantage | Alternative selectivity | Strong hydrophobic adsorption |
Surface Modification | Available | Available |
Typical Development | Biomolecule and polar compound media | Reversed-phase and adsorbent media |
Actual separation performance depends on the analyte, mobile phase, pore structure and surface chemistry.
Column Packing and Process Use
PM30UM-100A can be evaluated for packing:
Low-pressure chromatography columns
Preparative purification columns
Peptide separation columns
Pharmaceutical purification columns
Solid-phase extraction cartridges
Sample-cleanup devices
Custom research columns
Functionalized separation resins
The product is supplied as bulk microsphere media unless a prepacked column is specifically requested.
General Column Packing Guidance
Select a compatible slurry liquid.
Fully wet and disperse the microspheres.
Prepare a uniform slurry without visible aggregates.
Remove trapped air when necessary.
Transfer the slurry into the column.
Pack using controlled flow or pressure.
Avoid exceeding the validated pressure limit.
Equilibrate with the selected mobile phase.
Check the packed bed and flow stability.
Test separation performance with a suitable standard.
Packing conditions should be optimized according to the column size, bed height and intended separation method.
Surface Functionalization Options
SHBC can customize porous PMMA microspheres with different surface chemistries.
Available options may include:
Carboxyl groups
Amino groups
Hydroxyl groups
Epoxy groups
Sulfonic acid groups
Quaternary ammonium groups
Hydrophobic ligands
Hydrophilic coatings
Affinity ligands
Mixed-mode groups
Custom functional molecules
These modifications support the development of ion exchange, affinity, hydrophobic interaction and specialized adsorption media.
Why Choose SHBC
Controlled Particle Production
SHBC applies controlled polymerization, pore formation and particle-classification processes.
Defined Particle and Pore Size
PM30UM-100A combines a nominal 30µm particle size with a controlled 100Å porous structure.
Flexible Customization
Particle size, pore size, crosslinking degree, surface chemistry and packaging can be customized.
Reliable Batch Supply
Controlled manufacturing and quality inspection support consistent product performance between batches.
Scale-Up Manufacturing
SHBC supports laboratory samples, pilot-scale testing and industrial bulk production.
Technical Support
Technical assistance is available for media selection, slurry preparation, column packing and surface modification.
Custom and Bulk Supply
Shanghai SanYu Biotechnology Co., Ltd. supplies porous PMMA microspheres to pharmaceutical companies, biotechnology manufacturers, chromatography developers and research institutions.
Available services include:
Custom particle size
Custom pore size
Custom pore volume
Custom surface area
Custom crosslinking degree
Surface functionalization
Custom supply form
Custom packaging
Pilot-scale production
Bulk manufacturing
OEM and ODM services
Batch quality documentation
Please provide the target analyte, separation mode, column dimensions and estimated order quantity when requesting a quotation.
Frequently Asked Questions
What is PM30UM-100A?
PM30UM-100A is a porous crosslinked PMMA microsphere with a nominal particle size of 30µm and a pore size of 100Å.
What does 100Å mean?
It represents a nominal pore diameter of approximately 10nm inside the microspheres.
What analytes are suitable for 100Å pores?
The product can be evaluated for small molecules, pharmaceutical compounds, peptides and other relatively small analytes.
What is the advantage of 30µm particles?
The larger particles provide convenient packing, good flow performance and relatively low operating pressure.
Can it be used for protein purification?
The 100Å pores may be suitable for small proteins or protein fragments. Larger intact proteins may require a larger pore size.
Can it be used for low-pressure chromatography?
Yes. The 30µm particle size is suitable for low-pressure, preparative and process-development columns.
Can it be used for ion exchange chromatography?
The standard material does not contain ion-exchange groups. Charged functional groups can be customized.
How is PMMA different from PS/DVB?
PMMA has a more polar methacrylate surface, while PS/DVB generally provides stronger hydrophobic retention.
Is this a finished chromatography column?
No. PM30UM-100A is supplied as bulk porous microsphere media unless a prepacked column is ordered.
Can SHBC customize the pore size?
Yes. Particle size, pore size, crosslinking degree and surface chemistry can be customized.
Is bulk manufacturing available?
Yes. SHBC supports samples, pilot quantities and bulk production.
Storage and Handling
Store PM30UM-100A according to the SHBC technical documentation.
Keep the product tightly sealed and protected from contamination. Avoid exposure to unvalidated solvents, temperatures, pressures and strong oxidizing agents.
Request a Sample or Quotation
Contact Shanghai SanYu Biotechnology Co., Ltd. for samples, technical documentation, customized specifications or bulk pricing.
Product: 30µm Porous Crosslinked PMMA Microspheres
Catalog Number: PM30UM-100A
Brand: SHBC
Particle Size: 30µm
Pore Size: 100Å
Matrix: Crosslinked PMMA
Manufacturer: Shanghai SanYu Biotechnology Co., Ltd.
For research and industrial separation use only.