40um Porous Crosslinked PMMA Microspheres PM40UM-120A

40µm Porous Crosslinked PMMA Microspheres with 120Å Pores

SHBC PM40UM-120A is a porous crosslinked polymethyl methacrylate microsphere with a nominal particle size of 40µm and a pore size of 120Å.

Its uniform spherical structure, accessible internal pores and crosslinked polymer matrix make it suitable for low-pressure chromatography, solid-phase extraction, small-molecule purification and functional separation-media development.

Product Overview

PM40UM-120A combines a 40µm particle size with a controlled 120Å porous structure.

The relatively large particles support convenient column packing and good liquid flow. The internal pores increase the accessible surface area for adsorption and chromatographic interaction.

The product can be used as a standard porous PMMA medium or as a base matrix for further surface functionalization.

Key Features and Benefits

• Nominal particle size of 40µm

• Controlled pore size of 120Å

• Porous crosslinked PMMA matrix

• Uniform spherical morphology

• Good packed-bed flow

• Relatively low operating pressure

• Accessible internal surface area

• Suitable for small molecules and peptides

• Suitable for solid-phase extraction

• Flexible surface modification

• Custom specifications available

• Laboratory and bulk supply

Product Specifications

Particle-size distribution, pore volume, specific surface area and crosslinking degree are available according to the confirmed SHBC technical specification.

Benefits of 40µm Particles and 120Å Pores

Good Flow Performance

The 40µm particle size supports good liquid flow through gravity-flow, low-pressure and preparative columns.

Convenient Column Packing

The particles are easy to disperse, slurry-pack, wash and recover during process development.

Increased Accessible Surface

The porous structure provides more internal interaction area than nonporous PMMA microspheres.

Suitable for Smaller Analytes

The 120Å pores can be evaluated for small organic molecules, pharmaceutical compounds, peptides and selected biomolecule fragments.

Stable Crosslinked Structure

Crosslinking helps the particles maintain their spherical shape and porous structure during packing and washing.

Recommended Applications

Small-Molecule Separation

Suitable for method development involving organic compounds, active pharmaceutical ingredients, intermediates and related impurities.

Peptide Purification

The 120Å pore structure can be evaluated for the separation and purification of peptides and peptide-related compounds.

Pharmaceutical Process Development

Suitable for adsorption screening, impurity removal, intermediate purification and process polishing.

Solid-Phase Extraction

PM40UM-120A can be developed as a porous sorbent for:

• Sample cleanup

• Analyte concentration

• Impurity removal

• Pharmaceutical sample preparation

• Environmental sample preparation

Natural Product Purification

Suitable for screening plant extracts, fermentation products and other complex mixtures.

Low-Pressure Chromatography

The 40µm particles can be used in gravity-flow, low-pressure and preparative separation systems.

Functional Chromatography Resin

The porous PMMA matrix can be further modified to develop ion exchange, affinity, hydrophobic interaction or mixed-mode media.

Enzyme and Catalyst Carriers

After suitable activation, the particles can be evaluated as porous carriers for enzymes, catalysts and functional molecules.

Advantages of the Crosslinked PMMA Matrix

Alternative Separation Selectivity

The methacrylate polymer surface provides different interaction characteristics from strongly hydrophobic PS/DVB materials.

Moderate Surface Interaction

PMMA can provide milder retention for selected polar and moderately hydrophobic compounds.

No Silanol Groups

The polymer matrix does not contain residual silica silanol groups that may interact with basic analytes.

Flexible Functionalization

The PMMA matrix can be modified with charged, reactive, hydrophilic or affinity groups.

Good Process Handling

The 40µm spherical particles are suitable for packed columns, cartridges and batch adsorption processes.

PMMA vs. PS/DVB Microspheres

Actual separation performance depends on the analyte, mobile phase, pore accessibility and surface chemistry.

Column and Process Applications

PM40UM-120A can be evaluated for packing:

• Low-pressure chromatography columns

• Preparative purification columns

• Peptide separation columns

• Pharmaceutical purification columns

• Solid-phase extraction cartridges

• Sample-cleanup devices

• Functionalized resin columns

• Process-development columns

The product is supplied as bulk microsphere media unless a prepacked column is specifically requested.

Surface Functionalization Options

SHBC can discuss customized porous PMMA microspheres with different surface chemistries, including:

• Carboxyl groups

• Amino groups

• Hydroxyl groups

• Epoxy groups

• Sulfonic acid groups

• Quaternary ammonium groups

• Hydrophobic ligands

• Hydrophilic coatings

• Affinity ligands

• Mixed-mode groups

• Custom functional molecules

Functionalized versions can be developed for ion exchange, affinity purification, enzyme immobilization and specialized adsorption.

Why Choose SHBC

Controlled Particle Production

SHBC applies controlled polymerization, pore formation and particle-classification processes.

Defined Particle and Pore Size

PM40UM-120A combines a nominal 40µm particle size with a controlled 120Å porous structure.

Flexible Customization

Particle size, pore size, surface chemistry, crosslinking degree and packaging can be customized.

Reliable Batch Supply

Controlled manufacturing and quality inspection support consistent product performance between batches.

Scale-Up Manufacturing

SHBC supports laboratory samples, pilot-scale evaluation and industrial bulk production.

Technical Support

Technical assistance is available for microsphere selection, column packing, adsorption testing and surface modification.

Custom and Bulk Supply

Shanghai SanYu Biotechnology Co., Ltd. supplies porous PMMA microspheres to pharmaceutical companies, biotechnology manufacturers, chromatography developers and research institutions.

Available services include:

• Custom particle size

• Custom pore size

• Custom pore volume

• Custom surface area

• Custom crosslinking degree

• Surface functionalization

• Custom supply form

• Custom packaging

• Pilot-scale production

• Bulk manufacturing

• OEM and ODM services

• Batch quality documentation

Please provide the target compound, separation mode, mobile phase, column dimensions and estimated order quantity when requesting a quotation.

Frequently Asked Questions

What is PM40UM-120A?

PM40UM-120A is a porous crosslinked PMMA microsphere with a nominal particle size of 40µm and a pore size of 120Å.

What does 120Å mean?

It represents a nominal pore diameter of approximately 12nm inside the microspheres.

What analytes are suitable for 120Å pores?

The material can be evaluated for small organic molecules, pharmaceutical compounds, peptides and selected biomolecule fragments.

Is it suitable for intact antibodies?

The 120Å pores may limit access for intact antibodies and other large biomolecules. A larger-pore product is generally preferred.

What is the advantage of 40µm particles?

The 40µm particles provide good flow, convenient column packing and relatively low operating pressure.

Can it be used for low-pressure chromatography?

Yes. The particle size is suitable for gravity-flow, low-pressure and preparative systems.

Can it be used for ion exchange chromatography?

The standard product is non-functionalized. Ion-exchange groups can be introduced through customized surface modification.

How is it different from PM40UM-100A?

PM40UM-120A has slightly larger pores, which may improve internal access for larger analytes while maintaining suitability for small-molecule and peptide separation.

Is this a finished chromatography column?

No. PM40UM-120A is supplied as bulk porous microsphere media unless a prepacked column is ordered.

Is bulk manufacturing available?

Yes. SHBC supports samples, pilot quantities and bulk production.

Storage and Handling

Store PM40UM-120A according to the SHBC technical documentation.

Keep the product tightly sealed and protected from contamination. Avoid exposure to unvalidated solvents, temperatures, pressures and strong oxidizing agents.

Request a Sample or Quotation

Contact Shanghai SanYu Biotechnology Co., Ltd. for samples, technical documentation, customized specifications or bulk pricing.

Product: 40µm Porous Crosslinked PMMA Microspheres
Catalog Number: PM40UM-120A
Brand: SHBC
Particle Size: 40µm
Pore Size: 120Å
Matrix: Crosslinked PMMA
Manufacturer: Shanghai SanYu Biotechnology Co., Ltd.

For research and industrial separation use only.