100um Amino Magnetic Beads MNH100UM-10 5%

100µm Amino Magnetic Beads MNH100UM-10

MNH100UM-10 is a 100µm amino-functional magnetic bead suspension supplied at a solids content of 5%.

The product is developed as a large-particle magnetic solid phase for the covalent immobilization of antibodies, antigens, proteins, peptides, enzymes and other affinity ligands. It can be evaluated in immunoassay research, target enrichment, sample pretreatment, immunomagnetic separation, affinity capture and related bioseparation workflows.

Primary amino groups on the bead surface provide reactive sites for biomolecule immobilization through a suitable activation or crosslinking system. After ligand coupling, the functionalized beads can be magnetically collected, washed and redispersed during target-capture and separation procedures.

MNH100UM-10 is intended for biotechnology companies, research institutions, immunoassay developers and reagent manufacturers requiring a defined 100µm magnetic carrier for laboratory evaluation, pilot-scale validation and bulk production.

Because 100µm is a relatively large particle size, compatibility with a particular chemiluminescence, electrochemiluminescence or automated immunoassay platform must be confirmed experimentally.

What Are 100µm Amino Magnetic Beads?

100µm amino magnetic beads are magnetic microspheres with a nominal diameter of approximately 100 micrometers and primary amino groups on their surface.

The magnetic component enables collection with an appropriate magnetic separator. The amino-functional surface provides chemical reaction sites for immobilizing biological ligands.

The amino groups do not automatically form stable covalent bonds with every antibody or protein. A suitable activation or crosslinking system is normally required.

Depending on the functional groups available on the target ligand, developers may evaluate:

• Glutaraldehyde-mediated coupling;

• Activated carboxyl-to-amino coupling;

• Amine-to-sulfhydryl crosslinking;

• Amine-reactive bifunctional crosslinkers;

• Aldehyde-to-amino coupling;

• Other application-specific conjugation systems.

Commercial amino magnetic bead series include exact100µm particle options, confirming that this large-particle format is available for biomolecule immobilization and magnetic separation research.

Compared with small micrometer or nanoscale magnetic particles, 100µm beads generally exhibit more pronounced gravity-driven settling. They therefore require controlled mixing during sampling, coupling, incubation and filling.

MNH100UM-10 Product Specifications

The basis used to express the 5% solids content should be confirmed in the applicable technical data sheet. When a 5% concentration is expressed as w/v, it corresponds to 50mg of dry bead material per milliliter of suspension.

Particle-size distribution, magnetic properties, amino-group density, suspension medium, storage conditions and lot-release specifications should be confirmed through the applicable technical documentation and certificate of analysis.

Key Features of MNH100UM-10

Defined 100µm Particle Size

MNH100UM-10 provides a defined large-particle format rather than a broad 30–150µm particle-size range.

A specified nominal particle size can help researchers establish repeatable process conditions for:

• Bead dispensing;

• Ligand immobilization;

• Magnetic collection;

• Washing;

• Resuspension;

• Sample pretreatment;

• Pilot production;

• Lot-to-lot comparison.

Actual performance depends on particle-size distribution, density, magnetic loading, surface coating, buffer viscosity, bead concentration and magnetic separator design.

Amino-Functional Surface

The bead surface contains primary amino groups that can participate in covalent immobilization reactions.

Potential coupling targets include:

• Monoclonal antibodies;

• Polyclonal antibodies;

• Recombinant antigens;

• Natural proteins;

• Peptides;

• Enzymes;

• Streptavidin;

• Glycoproteins;

• Thiolated biomolecules;

• Carboxyl-containing ligands;

• Modified oligonucleotides;

• Other affinity ligands.

Large amino-functional magnetic carriers are commercially used to immobilize peptides, proteins and oligonucleotides through suitable chemical reagents such as glutaraldehyde.

Concentrated 5% Solids Suspension

The 5% formulation provides a concentrated starting material for preparing different bead working concentrations during:

• Coupling-method screening;

• Ligand-loading optimization;

• Blocking studies;

• Target-capture development;

• Sample-preparation research;

• Stability evaluation;

• Pilot-scale production;

• Manufacturing scale-up.

The suspension must be thoroughly homogenized before sampling because 100µm particles may settle during storage or temporary processing holds.

Clearly Observable Magnetic Collection

Under a suitable magnetic field, large micrometer-scale beads may form a clearly visible collection zone.

This can help researchers observe:

• Whether magnetic collection is complete;

• Whether beads are lost during aspiration;

• Whether aggregation has occurred;

• Whether washing is consistent;

• Whether the collected beads can be fully redispersed.

Suitable for Research-to-Production Projects

MNH100UM-10 can support projects involving:

• Initial material evaluation;

• Antibody-coupling development;

• Antigen immobilization;

• Sample pretreatment;

• Target enrichment;

• Immunomagnetic separation;

• Pilot-scale process validation;

• Batch-consistency testing;

• Bulk raw-material procurement.

Why Choose 100µm Magnetic Beads?

Particle size is an important design parameter in magnetic separation and immunoassay development.

A 100µm particle should not be selected simply because it is larger. It should be selected when its handling, collection or sample-processing properties match the intended workflow.

Easy Visual Observation

Large beads can be easier to observe during manual process development.

This may be useful when researchers need to monitor:

• Magnetic collection;

• Supernatant removal;

• Washing;

• Bead recovery;

• Aggregation;

• Redispersion.

Suitable for Manual and Semi-Automated Processing

MNH100UM-10 may be evaluated in manual or semi-automated workflows where large-particle handling is compatible with the reaction vessel, magnetic rack and liquid-transfer method.

Potential workflows include:

• Sample pretreatment;

• Affinity capture;

• Target enrichment;

• Cell or microorganism separation;

• Protein isolation;

• Large-particle immunoassay research.

Potential Use With Complex Samples

Large magnetic beads may be evaluated for target capture from samples containing cells, particles or relatively viscous components.

However, the sample matrix can affect:

• Bead aggregation;

• Magnetic recovery;

• Nonspecific adsorption;

• Ligand accessibility;

• Redispersion;

• Final assay background.

Matrix compatibility must therefore be tested using representative samples.

Important Surface-Area Tradeoff

For spherical particles of similar composition and density, increasing particle diameter decreases the available geometric surface area per unit mass.

Consequently, a protocol developed for1µm, 2µm or3µm beads should not be transferred directly to100µm beads.

The following parameters should be re-optimized:

• Bead dosage;

• Antibody-to-bead ratio;

• Coupling time;

• Mixing method;

• Sample-incubation time;

• Washing conditions;

• Final reagent concentration.

Instrument Compatibility Requires Validation

Not every automated CLIA or ECL instrument is designed for100µm particles.

The development team should evaluate:

• Pipette-tip internal diameter;

• Tubing dimensions;

• Reagent-reservoir mixing;

• Bead settling during standby;

• Reaction-cup geometry;

• Magnetic module configuration;

• Aspiration height;

• Wash efficiency;

• Bead carryover;

• Risk of fluidic blockage.

Commercial suppliers often distinguish small polymer magnetic beads used in analytical or diagnostic workflows from larger agarose magnetic carriers used mainly for separation and purification.

100µm vs Smaller Amino Magnetic Beads

The best bead size should be selected through side-by-side testing in the intended application.

Amino Surface Chemistry and Biomolecule Coupling

The most suitable coupling chemistry depends on the ligand’s available functional groups, desired orientation, retained biological activity and required storage stability.

Glutaraldehyde-Mediated Coupling

Glutaraldehyde can be used as a bifunctional reagent to activate an amino-functional surface before reaction with amino-containing proteins or antibodies.

A commercial amino magnetic bead protocol describes washing the beads, activating them with glutaraldehyde, adding the target biomolecule and blocking residual reactive sites after coupling.

Variables requiring optimization include:

• Glutaraldehyde concentration;

• Activation time;

• Reaction pH;

• Bead concentration;

• Ligand concentration;

• Coupling time;

• Mixing method;

• Blocking formulation.

Excessive activation may contribute to:

• Bead-to-bead crosslinking;

• Protein aggregation;

• Reduced ligand activity;

• Increased nonspecific binding;

• Poor bead redispersion.

Activated Carboxyl-to-Amino Coupling

Carboxyl groups on a protein, peptide or other ligand can be chemically activated before reaction with amino groups on MNH100UM-10.

Potential development variables include:

• Activation-buffer composition;

• Reaction pH;

• Carbodiimide concentration;

• NHS or Sulfo-NHS concentration;

• Ligand-to-bead ratio;

• Activation time;

• Coupling time;

• Quenching conditions.

Because proteins may contain multiple accessible carboxyl groups, coupling orientation may be heterogeneous. Functional binding should be evaluated together with chemical coupling yield.

BS3 and Other Amine-Reactive Crosslinkers

A homobifunctional amine-reactive crosslinker can connect amino groups on the bead surface with amino groups on a protein.

This route may be simple to evaluate, but it generally provides random ligand orientation because multiple primary amino groups may participate in the reaction.

Important variables include:

• Crosslinker concentration;

• Ligand concentration;

• Reaction pH;

• Reaction time;

• Mixing;

• Quenching;

• Retained protein activity.

Sulfo-SMCC Amine-to-Sulfhydryl Coupling

Sulfo-SMCC contains an amine-reactive NHS ester and a sulfhydryl-reactive maleimide group.

The NHS-ester end can react with amino groups on the bead surface. The maleimide end can subsequently react with a thiolated antibody, protein, peptide or oligonucleotide.

This route may be considered when:

• The ligand naturally contains an accessible sulfhydryl group;

• The ligand has been selectively thiolated;

• Greater functional-group selectivity is required;

• Random amine-to-amine crosslinking is undesirable.

Aldehyde-to-Amino Coupling

Aldehyde-containing carbohydrates, glycoproteins or modified ligands may be evaluated for immobilization through reductive amination.

The buffer, reductant, pH, ligand concentration and reaction time must be optimized for the selected molecule.

Selecting the Coupling Route

The best coupling condition is the one that produces acceptable functional performance, not necessarily the highest measured protein loading.

Applications in Immunoassay and Target Enrichment

Large-Particle Magnetic Immunoassay Research

MNH100UM-10 may be evaluated as a large-particle magnetic solid phase in immunoassay method development.

A capture antibody or antigen can be immobilized on the bead surface. The functionalized beads can then capture the target from a sample before magnetic collection and washing.

The developer must validate:

• Target-capture efficiency;

• Bead dosage;

• Ligand density;

• Mixing;

• Magnetic recovery;

• Nonspecific binding;

• Detection compatibility;

• Assay precision.

Chemiluminescence Immunoassay Research

MNH100UM-10 may be evaluated in chemiluminescence immunoassay research when the instrument and reaction vessel can handle100µm particles.

Key development parameters include:

• Capture-ligand density;

• Bead dosage;

• Sample-incubation time;

• Magnetic washing;

• Enzyme-labelled detection reagent;

• Chemiluminescent substrate;

• Background signal;

• Signal-to-background ratio.

The product should not be assumed to be compatible with every automated CLIA analyzer.

Electrochemiluminescence Immunoassay Research

MNH100UM-10 may also be evaluated in electrochemiluminescence research if the large particle format is compatible with the electrode region, magnetic module and fluidic system.

The development team should confirm:

• Magnetic positioning near the reaction area;

• Electrode compatibility;

• Signal-label compatibility;

• Washing efficiency;

• Particle interference with signal reading;

• Bead recovery;

• Fluidic-path compatibility.

Sample Pretreatment

Antibody-, protein- or affinity-ligand-coupled MNH100UM-10 can be evaluated for removing, concentrating or enriching target materials before downstream detection.

Potential targets include:

• Proteins;

• Cells;

• Microorganisms;

• Biological particles;

• Other affinity-recognized analytes.

Immunomagnetic Separation

Ligand-functionalized100µm beads may be evaluated for isolating target cells, microorganisms or other relatively large biological entities.

The optimal bead-to-target ratio and mixing method should be established experimentally.

Affinity Capture and Protein Isolation

Protein- or antibody-coupled beads can be evaluated for:

• Affinity capture;

• Immunoprecipitation research;

• Protein enrichment;

• Antibody isolation;

• Buffer exchange workflows;

• Sample cleanup.

Large amino magnetic bead products are commonly positioned for protein, peptide and oligonucleotide immobilization and separation workflows.

Recommended Antibody and Protein Coupling Workflow

The following workflow is a general development framework and is not a validated product-specific protocol.

Step 1: Characterize the Ligand

Before coupling, record:

• Ligand identity;

• Molecular weight;

• Concentration;

• Purity;

• Original buffer;

• Stabilizing additives;

• Available amino groups;

• Available carboxyl groups;

• Available sulfhydryl groups;

• Biological activity.

The original ligand formulation may require buffer exchange if it contains components that interfere with the selected coupling chemistry.

Step 2: Select the Coupling Method

Choose the reaction according to the ligand and intended application:

• Glutaraldehyde-mediated coupling;

• Activated carboxyl-to-amino coupling;

• Amine-reactive bifunctional crosslinking;

• Amine-to-sulfhydryl coupling;

• Reductive amination;

• Other functional-group-specific chemistry.

Step 3: Fully Resuspend MNH100UM-10

Mix the original suspension until homogeneous before removing an aliquot.

Suitable methods may include:

• Gentle inversion;

• Roller mixing;

• End-over-end rotation;

• Controlled low-speed vortexing;

• Another validated low-shear method.

Because100µm beads settle relatively quickly, maintain mixing when preparing several aliquots from the same container.

Step 4: Determine the Bead Quantity

Evaluate several bead quantities during development.

The optimal dosage depends on:

• Target concentration;

• Ligand-loading level;

• Sample volume;

• Required recovery;

• Sample matrix;

• Magnetic separator;

• Assay format.

Step 5: Wash and Exchange the Buffer

Collect the beads using a compatible magnetic separator.

Remove the original suspension medium and wash with a buffer compatible with the selected coupling reaction.

Do not allow the beads to dry. Commercial amino magnetic bead suppliers similarly warn that drying or freezing may promote aggregation and make complete redispersion difficult.

Step 6: Activate the Beads or Ligand

Control:

• Crosslinker concentration;

• Bead concentration;

• Activation pH;

• Reaction time;

• Temperature;

• Mixing rate;

• Reagent-addition order.

Step 7: Add the Antibody or Protein

Evaluate multiple ligand-to-bead ratios.

A higher ligand input does not always produce better target capture. Excessive loading may cause surface crowding, reduced ligand accessibility or increased nonspecific binding.

Step 8: Maintain a Uniform Suspension

Use gentle continuous or intermittent mixing during activation and coupling.

This step is particularly important for100µm particles because settling can cause uneven surface exposure and inconsistent ligand loading.

Step 9: Quench or Block Residual Sites

After coupling, add a suitable quenching or blocking reagent.

The blocker should reduce nonspecific interactions without interfering with target recognition or downstream detection chemistry.

Step 10: Wash the Coupled Beads

Remove:

• Unbound ligand;

• Residual crosslinker;

• Reaction by-products;

• Excess blocker.

Use consistent magnetic collection and aspiration conditions.

Step 11: Resuspend in Storage Buffer

Potential formulation variables include:

• Buffer type;

• pH;

• Ionic strength;

• Protein stabilizer;

• Synthetic polymer;

• Surfactant;

• Preservative;

• Sugar or polyol;

• Final bead concentration.

Step 12: Evaluate Coupling Performance

Recommended evaluation items include:

• Ligand depletion from the supernatant;

• Chemical coupling yield;

• Functional target-binding capacity;

• Nonspecific binding;

• Magnetic recovery;

• Redispersion;

• Assay signal;

• Precision;

• Accelerated stability;

• Real-time stability.

How to Optimize MNH100UM-10 in an Immunoassay

Optimize Bead Dosage

Compare several bead quantities in the complete assay.

Insufficient beads may limit capture capacity, while excessive beads may increase reagent consumption, sedimentation, background or washing requirements.

Optimize Ligand Density

Prepare conjugates with low, medium and high ligand-loading levels.

Compare:

• Coupling yield;

• Functional binding;

• Blank signal;

• Positive signal;

• Signal-to-background ratio;

• Recovery;

• Precision;

• Storage stability.

Optimize Mixing Conditions

Evaluate:

• Continuous versus intermittent mixing;

• Rotation speed;

• Mixing duration;

• Vessel geometry;

• Foam formation;

• Bead uniformity;

• Ligand stability.

Mixing should keep the particles suspended without damaging the biological ligand.

Optimize Magnetic Collection

Confirm:

• Magnet strength;

• Collection time;

• Vessel geometry;

• Sample volume;

• Collection-zone position;

• Residual liquid volume;

• Bead loss during aspiration;

• Recovery after repeated washes.

Optimize Redispersion

Ensure that the collected beads can be completely redispersed after every magnetic collection step.

Incomplete redispersion may cause:

• Variable bead dosage;

• Lower target recovery;

• Poor precision;

• Uneven reagent filling;

• Instrument blockage;

• Inconsistent analytical signal.

Evaluate Matrix Effects

Depending on the intended application, evaluate the effects of:

• High protein concentration;

• Lipids;

• Hemoglobin;

• Bilirubin;

• Anticoagulants;

• Cells;

• Particulate materials;

• Sample preservatives;

• Other potentially interfering components.

Evaluate Instrument Compatibility

For automated or semi-automated systems, assess:

• Reagent-reservoir mixing;

• Settling during standby;

• Pipette-tip dimensions;

• Tubing dimensions;

• Dispensing accuracy;

• Magnetic collection;

• Aspiration height;

• Wash efficiency;

• Bead carryover;

• Risk of blockage.

Quality Control for Research and Batch Production

MNH100UM-10 should be evaluated using both physical characterization and application-specific functional testing.

Appearance and Dispersion

Inspect:

• Suspension appearance;

• Visible aggregates;

• Sedimentation behavior;

• Homogeneity after mixing;

• Ease of redispersion;

• Stability during process holds.

Particle Size and Distribution

Confirm the nominal100µm particle size using an appropriate analytical method.

For manufacturing projects, monitor both average particle size and particle-size distribution.

Solids Content

Verify solids content because it affects:

• Bead dosage;

• Ligand consumption;

• Coupling calculations;

• Production yield;

• Final reagent concentration.

Amino Surface Reactivity

Use a standardized crosslinking reaction or model ligand to evaluate the functional reactivity of the amino surface.

Magnetic Collection Performance

Define standardized test conditions, including:

• Magnet type;

• Vessel;

• Sample volume;

• Buffer;

• Bead concentration;

• Collection time;

• Temperature.

Coupling Performance

Conduct a standardized coupling test using a representative antibody or protein.

Potential analytical methods include:

• Protein depletion from the supernatant;

• Colorimetric protein analysis;

• Fluorescent ligand measurement;

• Functional target-binding testing;

• Immunoassay signal evaluation.

Nonspecific Binding

Compare:

• Untreated beads;

• Activated beads;

• Blocked beads;

• Ligand-coupled beads;

• Negative sample matrices;

• Potential interfering materials.

Functional Performance

Depending on the intended application, evaluate:

• Blank signal;

• Target recovery;

• Positive-sample signal;

• Signal-to-background ratio;

• Precision;

• Specificity;

• Recovery;

• Linearity;

• Carryover;

• Stability.

Lot-to-Lot Consistency

For routine manufacturing, establish acceptance ranges for critical physical and functional parameters.

Final raw-material approval should be based on performance in the complete workflow rather than particle characterization alone.

Scale-Up and Bulk Supply for Reagent Manufacturers

MNH100UM-10 can support projects progressing from laboratory evaluation to batch manufacturing.

Evaluation Stage

Evaluation samples can be used to screen:

• Coupling chemistry;

• Crosslinker concentration;

• Ligand-to-bead ratio;

• Blocking formulation;

• Mixing conditions;

• Magnetic separation;

• Target recovery;

• Assay background.

Pilot-Scale Stage

Pilot quantities can support:

• Coupling-process confirmation;

• Sample-preparation development;

• Reagent formulation;

• Instrument compatibility testing;

• Stability studies;

• Filling-process evaluation;

• Initial batch-consistency testing.

Batch-Production Stage

Bulk supply planning may include:

• Annual demand;

• Forecasted purchasing schedule;

• Packaging volume;

• Quality specifications;

• Technical documentation;

• Reserved-lot requirements;

• Change-control expectations;

• Safety-stock planning.

Scale-Up Considerations

A laboratory procedure should not be scaled only by multiplying reagent volumes.

The following factors must also be revalidated:

• Reaction-vessel geometry;

• Agitation efficiency;

• Bead-suspension uniformity;

• Addition sequence;

• Temperature distribution;

• pH control;

• Magnetic collection;

• Washing efficiency;

• Process hold time;

• Final filling homogeneity.

Maintaining a uniform suspension during coupling and filling is particularly important for100µm beads.

Custom Amino Magnetic Bead Services

SHBC can evaluate customized requirements for biotechnology companies, research institutions and reagent manufacturers.

Potential customization options include:

• Alternative particle sizes;

• Customized solids content;

• Adjusted amino-group density;

• Customized suspension buffer;

• Alternative preservative systems;

• Customer-specified pH;

• Special packaging volumes;

• Pilot-scale manufacturing;

• Bulk manufacturing;

• OEM packaging;

• Private-label service;

• Customer-specific quality-control testing.

Customization feasibility depends on the requested specifications, application requirements, validation expectations and order quantity.

Storage and Handling Recommendations

Store MNH100UM-10 according to the product label, technical data sheet and lot-specific certificate of analysis.

General recommendations include:

• Mix thoroughly before sampling;

• Maintain suspension uniformity during dispensing;

• Use clean and calibrated liquid-handling equipment;

• Avoid allowing the particles to dry;

• Prevent microbial and chemical contamination;

• Confirm buffer compatibility before buffer exchange;

• Avoid freezing unless specifically validated;

• Avoid unnecessary exposure to extreme temperatures;

• Record the product lot number;

• Evaluate finished-conjugate stability separately.

Commercial suppliers of large amino magnetic particles similarly recommend thorough mixing before use and caution against freezing or drying because these conditions may promote aggregation and poor redispersion.

Frequently Asked Questions

What is MNH100UM-10?

MNH100UM-10 is a100µm amino-functional magnetic bead suspension supplied at5% solids for biomolecule coupling, immunoassay research, target enrichment and magnetic separation.

What functional group is present on the bead surface?

The particle surface contains primary amino groups, commonly written as NH₂ groups.

Which biomolecules can be coupled to MNH100UM-10?

Potential coupling targets include antibodies, antigens, proteins, peptides, enzymes, streptavidin, glycoproteins and suitably modified oligonucleotides.

Can antibodies be coupled directly to the beads?

A suitable activation or crosslinking system is normally required. The optimal chemistry depends on the available functional groups of the antibody and the desired conjugate structure.

Which coupling methods can be evaluated?

Potential routes include glutaraldehyde-mediated coupling, activated carboxyl-to-amino coupling, amine-reactive crosslinkers, amine-to-sulfhydryl coupling and reductive amination.

Why choose a 100µm particle size?

The100µm format may be selected when a process requires a large magnetic carrier, clearly observable magnetic collection, manual washing, sample pretreatment or capture of relatively large targets.

How do 100µm beads differ from smaller beads?

Compared with smaller particles of similar composition,100µm beads generally settle faster, provide fewer particles and less geometric surface area per unit mass, and require different mixing, coupling and dispensing conditions.

Do 100µm magnetic beads settle?

Yes. Large particles are expected to settle during storage and incubation. The suspension should be mixed before sampling and maintained under suitable mixing during processing.

Can MNH100UM-10 be used in immunoassays?

It can be evaluated as a large-particle magnetic solid phase in immunoassay research. The assay format, target, magnetic separator and detection system must be validated experimentally.

Can MNH100UM-10 be used for chemiluminescence immunoassays?

It may be evaluated for CLIA research when the reaction vessel, magnetic module and liquid-handling system are compatible with100µm particles. Compatibility should not be assumed for every analyzer.

Can it be used for electrochemiluminescence immunoassays?

The product may be evaluated in ECL research, but compatibility with the electrode, magnetic positioning, fluidic system and signal-reading process must be confirmed experimentally.

Is 100µm a common particle size for automated immunoassay analyzers?

Small micrometer particles are more commonly used in many analytical immunoassay platforms. A100µm particle requires specific validation of pipetting, magnetic collection, washing and carryover.

Does 5% solids mean the product is ready to use without dilution?

No. The5% suspension is a concentrated raw material. The appropriate working concentration should be determined during coupling and application development.

Does higher antibody loading always improve performance?

No. Excessive ligand density may cause steric crowding, reduced target accessibility or increased nonspecific binding.

How can coupling efficiency be evaluated?

One approach is to compare the initial ligand concentration with the unbound ligand remaining in the post-coupling supernatant. Functional target-binding activity should also be measured.

How should MNH100UM-10 be mixed?

Use a validated low-shear method such as inversion, roller mixing or end-over-end rotation until the suspension is homogeneous.

What should be checked if magnetic collection is incomplete?

Check magnet strength, collection time, bead concentration, liquid viscosity, particle aggregation and vessel geometry.

Can MNH100UM-10 be used with automated equipment?

It can be evaluated for automated or semi-automated equipment, but tip dimensions, tubing, dispensing, mixing, magnetic collection, aspiration and washing must be validated.

Is MNH100UM-10 a finished diagnostic reagent?

No. MNH100UM-10 is supplied as a raw material for research and reagent development. The customer is responsible for validating the finished reagent, manufacturing process and intended use.

Are evaluation samples available?

Evaluation samples can be discussed according to the intended application, coupling target and required test quantity.

Is bulk supply available?

Pilot-scale and bulk supply can be arranged for qualified research, development and manufacturing projects.

Can the concentration, buffer or packaging be customized?

Customized solids content, suspension buffer, amino surface parameters and packaging formats may be evaluated according to project requirements.

Request a Sample or Bulk Quotation

Contact SHBC to request an evaluation sample, technical information or bulk quotation for MNH100UM-10 100µm Amino Magnetic Beads.

Please provide:

• Intended application;

• Target antibody, antigen or protein;

• Preferred coupling method;

• Sample matrix;

• Required evaluation quantity;

• Estimated pilot quantity;

• Expected annual demand;

• Preferred packaging volume;

• Required technical documents;

• Required quality documents;

• Target development schedule;

• Custom specification requirements.

SHBC supports amino magnetic bead projects from early coupling evaluation and target-capture optimization to pilot production and bulk manufacturing.